Table 5.
LME best fit models for each brain region by sex and sample. Highest-order best fit polynomial model summary reported. Test refers to the highest-order model compared to previous sequential model tested (1 = null model, 2 = linear, 3 = quadratic, 4= cubic) and its associated Likelihood Ratio (L.Ratio) and p-value (bold highlights p<.05).
| THALAMUS | ||||
|---|---|---|---|---|
| FEMALES | Model Result | Test | L. Ratio | p-value |
| PIT | Null Model | 1 vs 2 | 0.75 | 0.386 |
| NCD | Quadratic Age Model | 2 vs 3 | 15.35 | 0.000 |
| OADS | Null Model | 1 vs 2 | 0.83 | 0.362 |
| MALES | Model Result | Test | L. Ratio | p-value |
| PIT | Quadratic Age Model | 2 vs 3 | 7.29 | 0.007 |
| NCD | Cubic Age Model | 2 vs 4 | 12.47 | 0.002 |
| OADS | Linear Age Model | 1 vs 2 | 6.91 | 0.009 |
| PALLIDUM | ||||
| FEMALES | Model Result | Test | L. Ratio | p-value |
| PIT | Quadratic Age Model | 2 vs 3 | 8.61 | 0.003 |
| NCD | Cubic Age Model | 2 vs 4 | 6.50 | 0.039 |
| OADS | Quadratic Age Model | 2 vs 3 | 5.13 | 0.024 |
| MALES | Model Result | Test | L. Ratio | p-value |
| PIT | Linear Age Model | 1 vs 2 | 4.93 | 0.026 |
| NCD | Null Model | 1 vs 2 | 0.49 | 0.482 |
| OADS | Quadratic Age Model | 2 vs 3 | 8.14 | 0.004 |
| CAUDATE | ||||
| FEMALES | Model Result | Test | L. Ratio | p-value |
| PIT | Linear Age Model | 1 vs 2 | 13.70 | 0.000 |
| NCD | Quadratic Age Model | 2 vs 3 | 5.02 | 0.025 |
| OADS | Linear Age Model | 1 vs 2 | 65.50 | <.0001 |
| MALES | Model Result | Test | L. Ratio | p-value |
| PIT | Null Model | 1 vs 2 | 3.45 | 0.063 |
| NCD | Quadratic Age Model | 2 vs 3 | 4.61 | 0.032 |
| OADS | Linear Age Model | 1 vs 2 | 38.91 | <.0001 |
| PUTAMEN | ||||
| FEMALES | Model Result | Test | L. Ratio | p-value |
| PIT | Linear Age Model | 1 vs 2 | 19.52 | <.0001 |
| NCD | Linear Age Model | 1 vs 2 | 33.31 | <.0001 |
| OADS | Cubic Age Model | 2 vs 4 | 8.90 | 0.012 |
| MALES | Model Result | Test | L. Ratio | p-value |
| PIT | Null Model | 1 vs 2 | 0.38 | 0.537 |
| NCD | Quadratic Age Model | 2 vs 3 | 3.96 | 0.047 |
| OADS | Linear Age Model | 1 vs 2 | 25.40 | <.0001 |
| NUCLEUS ACCUMBENS | ||||
| FEMALES | Model Result | Test | L. Ratio | p-value |
| PIT | Null Model | 1 vs 2 | 0.43 | 0.510 |
| NCD | Null Model | 1 vs 2 | 2.70 | 0.100 |
| OADS | Linear Age Model | 1 vs 2 | 21.82 | <.0001 |
| MALES | Model Result | Test | L. Ratio | p-value |
| PIT | Null Model | 1 vs 2 | 0.09 | 0.764 |
| NCD | Null Model | 1 vs 2 | 0.09 | 0.766 |
| OADS | Null Model | 1 vs 2 | 0.12 | 0.725 |
| HIPPOCAMPUS | ||||
| FEMALES | Model Result | Test | L. Ratio | p-value |
| PIT | Cubic Age Model | 2 vs 3 | 6.66 | 0.036 |
| NCD | Quadratic Age Model | 2 vs 3 | 14.20 | 0.000 |
| OADS | Quadratic Age Model | 2 vs 3 | 14.46 | 0.000 |
| MALES | Model Result | Test | L. Ratio | p-value |
| PIT | Null Model | 1 vs 2 | 0.57 | 0.452 |
| NCD | Null Model | 1 vs 2 | 0.49 | 0.482 |
| OADS | Cubic Age Model | 2 vs 3 | 8.66 | 0.013 |
| AMYGDALA | ||||
| FEMALES | Model Result | Test | L. Ratio | p-value |
| PIT | Quadratic Age Model | 2 vs 3 | 4.60 | 0.032 |
| NCD | Quadratic Age Model | 2 vs 3 | 10.92 | 0.001 |
| OADS | Linear Age Model | 1 vs 2 | 6.19 | 0.013 |
| MALES | Model Result | Test | L. Ratio | p-value |
| PIT | Linear Age Model | 1 vs 2 | 4.91 | 0.027 |
| NCD | Cubic Age Model | 2 vs 3 | 8.53 | 0.014 |
| OADS | Linear Age Model | 1 vs 2 | 21.36 | <.0001 |