. Author manuscript; available in PMC: 2019 May 1.

Published in final edited form as: Am J Transplant. 2018 Mar 5;18(5):1262–1269. doi: 10.1111/ajt.14674

Table 1.

Graft survival, histology of heart-kidney and isolated kidney recipients

Group	Organ	Protocol	Animal #	Graft survival	Histology at 3 months
1	Heart & Kidney	Brain death × 4hrs	21690	>100 days	Heart: ISHLT 0R Kidney: i1t2+TOLS
1	Heart & Kidney	Brain death × 4hrs	21505	16 days (died of PE)	n/a (i0t1+TOLS at 16 days)
2	Heart & Kidney	Brain death × 8hrs	22025	>100 days	Heart: ISHLT 0R Kidney: i1t3+TOLS
2	Heart & Kidney	Brain death × 8hrs	22029	>100 days	Heart: ISHLT 1R Kidney: i0t2+TOLS
3	Heart & Kidney	Brain death × 4hrs Cold ischemia × 4hrs	21740	>100 days	Heart: ISHLT 0R Kidney: i1t2+TOLS
3	Heart & Kidney	Brain death × 4hrs Cold ischemia × 4hrs	22026	>100 days	Heart: ISHLT 0R Kidney: i1t2 no TOLS
4	Heart & Kidney	Warm renal ischemia × 80mins	21420	>100 days	Heart: ISHLT 0R Kidney: i1t2+TOLS
4	Heart & Kidney	Warm renal ischemia × 80mins	21736	>100 days	Heart: ISHLT 0R Kidney: i1t2+TOLS
5	Kidney	Brain death × 4hrs	18055	>100 days	i1t2+TOLS
			18225	>100 days	i0t3+TOLS
			18226	>100 days	i1t2+TOLS
			18353	>100 days	i0t2+TOLS

POD, postoperative day; ISHLT, International Society for heart and lung transplantation; ACR, acute cellular rejection; PE, pulmonary embolism; TOLS, Treg-rich Organized Lymphoid Structure; i, t Banff lesion scores for interstitial inflammation and tubulitis, respectively.