Table 1.

Study Design Similarities and Differences between the Mental Stress Ischemia: Prognosis and Genetic Influences Study, or MIPS and Myocardial Infarction and Mental Stress Study, or MIMS

Characteristics	MIPS Study	MIMS Study
Sample size	636	314
Age range	30 to 80 years	18 to 60 years
Sex ratio (M/F)	70:30	50:50
Inclusion criteria	Significant history of coronary artery disease during their lifetime: Angiographically proven disease including at least 1 major vessel with evidence of disease Prior myocardial infarction (>3 months) Abnormal coronary intravascular ultrasound for at least 1 vessel Previous bypass surgery or post percutaneous intervention (> 1 year) Positive nuclear scan or exercise stress test)	Documented history of myocardial infarction within the previous 8 months
Common exclusion criteria	History of unstable angina or acute MI within the past week Severe comorbid medical or psychiatric disorder that could interfere with study results, such as cancer, renal failure, current alcohol or substance abuse or schizophrenia Uncontrolled hypertension and/or deemed to be unfit to withhold anti-ischemic medications by study cardiologist Weight over 400 lbs Pregnancy or breastfeeding
Study-specific exclusion criteria	Individuals with inflammatory diseases (like rheumatoid arthritis, lupus), on dialysis, or having any organ transplant excluded	No such exclusion criteria