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. 2018 Apr 20;8:6348. doi: 10.1038/s41598-018-24769-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Lasso-penalized bootstrap-enhanced regression of miRNA plasma expression. (A) Box plots showing the distribution of regression coefficients for predictors in bootstrap samples; (B) Variable importance plot; (C) ROC curves for classification of combined dataset using bootstrap-enhanced model (solid), naive non-optimized model (dashed).