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. 2018 Apr 20;8:6333. doi: 10.1038/s41598-018-24568-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional inhibition of CC chemokines by individual and “two-warhead” evasins. (A–C) Neutralization of CCL5 induced THP-1 cell migration by P1243, P1243:G4S:P1156, and P1156:G4S:P1243 respectively. Y-axis shows cell count of THP-1 cells migrating through to the bottom chamber in response to EC₈₀ dose of CCL5. In each case, data from a representative experiment are shown as mean ± s.e.m. of three technical replicates. X-axis shows CKBP concentration (Log₁₀ Molar). IC₅₀ values (M) indicated in each figure were estimated by fitting an agonist response curve with 4 parameters²². (D–F) Summary IC₅₀ data (mean ± s.e.m., and individual data points from three biological replicates) of the indicated CKBPs against CCL5, CCL3 and CCL3L1 respectively. Y-axis shows IC₅₀ (logarithmic scale, M), and x-axis shows each CKBP. CC chemokines were assayed using THP-1 cell migration. Each chemokine was assayed at its EC₈₀ dose. There were no statistically significant differences between the mean IC₅₀ values in each figure.