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. 2018 Apr 20;8:6306. doi: 10.1038/s41598-018-24782-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dlk1 expression is upregulated in Hox mutant kidneys. Dlk1 expression is very low in the wild type metanephros at E12.5 (N’), E13.5 (B’,D’), E14.5 (E’, image from Eurexpress.org), E15.5 (F’, image from Allen Brain Atlas, brain-map.org), E16.5 (L’), E18.5 (P’) and adult (T’). In contrast, the wild type mesonephros shows DLK1 expression at E12.5 (G’–J’). Hoxa9,10−/−11+/− HoxC−/− mutant kidneys show DLK1 expression in multiple cell types, including proximal tubules, as well as interstitial cells (Q’,R’), and DLK1 is upregulated in Hox cystic kidneys as well (U’,V’). Hoxc9,10,11−/− Hoxd9,10,11−/− show increased DLK1 expression along the ureteric stalks (CC’, arrow) and in developing nephrons (KK’, arrowheads) in E13.5 whole mount IF. N = 3 per immunoassay.