Table 3.
Details on viral nucleic acid detection performed concurrently with HLH compared to detection in specimens from haemato-/oncologic patients without HLH. Results from blood specimens were analysed. Only for BKV, results from urine specimens were analysed additionally. BKV was only tested in blood specimens from four HLH patients with BK viruria and was positive in two (50%) of them. Detection rates of viruses detected concurrently with HLH only in one patient each were not compared (−)
| Virus | Patients tested concurrently with HLH | Specimens tested in patients without HLH | |||||
|---|---|---|---|---|---|---|---|
| Patients tested | Patients positive | Positive (% of tested) | Specimens tested | Specimens positive | Positive (% of tested) | p value | |
| Commonly tested viruses | |||||||
| BKV (urine) | 13 | 7 | 53.8% | 1.453 | 385 | 26.5% | 0.051 |
| HHV-6 | 18 | 6 | 33.3% | 3.721 | 286 | 7.7% | 0.002 |
| BKV (blood) | 7 | 2 | 28.6% | 1.467 | 57 | 3.9% | 0.029 |
| EBV | 18 | 5 | 27.8% | 4.323 | 425 | 9.8% | 0.027 |
| CMV | 17 | 4 | 23.5% | 2.458 | 84 | 3.4% | 0.002 |
| ADV | 18 | 3 | 16.7% | 3.439 | 24 | 0.7% | < 0.001 |
| PVB19 | 18 | 3 | 16.7% | 3.631 | 148 | 4.1% | 0.036 |
| HHV-7 | 13 | 1 | 7.7% | – | – | – | – |
| HSV-1 | 15 | 1 | 6.7% | – | – | – | – |
| HSV-2 | 15 | 0 | 0.0% | – | – | – | – |
| VZV | 17 | 0 | 0.0% | – | – | – | – |
| EV | 17 | 0 | 0.0% | – | – | – | – |
| Occasionally tested viruses | |||||||
| Influenza A | 6 | 1 | 16.7% | – | – | – | – |
| RSV | 7 | 1 | 14.3% | – | – | – | – |
| HHV-8 | 9 | 1 | 11.1% | – | – | – | – |
| JCV | 9 | 1 | 11.1% | – | – | – | – |
| Influenza B | 5 | 0 | 0.0% | – | – | – | – |
ADV adenovirus, BKV BK virus, CMV cytomegalovirus, EBV Epstein-Barr virus, EV enterovirus, HHV human herpesvirus, HSV herpes simplex virus, JCV JC virus, PVB19 parvovirus B19, RSV respiratory syncytial virus, VZV varicella zoster virus