Fig. 4.

The mean area of ethanol lesions and accompanying changes in the GBF in rats pretreated with curcumin (50 mg/kg i.g.), l-arginine (200 mg/kg i.g.) alone or in those pretreated with a combination of L-NNA administered in a dose of 20 mg/kg i.p. and curcumin (50 mg/kg i.g.) with or without l-arginine (200 mg/kg i.g.). The results are mean ± SEM recorded in seven rats per group. The asterisk indicates a significant change (p < 0.05) relative to the respective values recorded in the vehicle-control group. The asterisk and cross indicate a statistically significant change (p < 0.05) compared with the values obtained in animals pretreated with l-arg alone. The cross indicates a statistically significant change (p < 0.05) relative to the values obtained in animals pretreated with curcumin. Double crosses indicate a significant change (p < 0.05) relative to animals treated with a combination of L-NNA and curcumin