Fig. 5.

The mean area of ethanol-induced gastric lesions and the changes in gastric blood flow (GBF) in rats with intact sensory nerves or in those with capsaicin denervation pretreated with CGRP (10 μg/kg s.c.) or curcumin (50 mg/kg i.g.) applied alone or administered in combination with CGRP (10 μg/kg s.c.). The results are mean ± SEM from 6 to 8 rats per group. The asterisk indicates a significant change (p < 0.05) relative to the vehicle-control values. The double asterisk indicate a significant change (p < 0.05) relative to the values obtained in animals pretreated with CGRP alone. The asterisk and cross indicate a statistically significant change (p < 0.05) as compared to treatment with curcumin alone. The cross indicates a significant change (p < 0.05) as compared with values obtained in vehicle-control- or curcumin-treated rats with intact sensory nerves. The double crosses indicate a significant change (p < 0.05) compared with capsaicin-denervated rats treated with curcumin