Fig. 2.

Association of BPA with MEST promoter methylation and MEST expression in cord blood a MEST promoter methylation (=mean of MassARRAY amplicon) in cord blood of low (< 25%; lower quartile (LQ), n = 102) and high (> 75%, upper quartile (UQ), n = 101) BPA-exposed children. p value from MWU-test. b MEST promoter methylation and expression in cord blood are correlated in children with high prenatal exposure to BPA (UQ, n = 94), while MEST expression is not correlated with MEST promoter methylation in lowly exposed children (remaining 75%, n = 267). R and p values from Spearman correlation. c Mediator model for the association of prenatal BPA exposure, cord blood MEST promoter methylation and expression. Models were adjusted for gender of the child, smoking during pregnancy, parental school education, solid food introduction, week of gestation at delivery, number of household members, and early delivery. Shown are effect sizes with *p < 0.05