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. 2018 Apr 20;15:117. doi: 10.1186/s12974-018-1154-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Upregulation of trigeminal ganglionic IL-1β, COX-2, phospho-CREB, and Nav1.7 accompanied with decrease in the head withdrawal threshold after induction of TMJ inflammation. a Upregulation of IL-1β, COX-2, and Nav1.7 mRNA expressions in TG after induction of TMJ inflammation for 24 h. Independent samples t test, *P < 0.05 versus the control group; n = 3. b Upregulation of IL-1β, COX-2, phospho-CREB, and Nav1.7 protein expressions in TG after induction of TMJ inflammation for 24 h. Quantification of protein expressions were presented as fold change of the control group (lower panel). Independent samples t test, *P < 0.05 versus the control group; n = 3. c Decrease in the head withdrawal threshold after induction of TMJ inflammation for 24 h. Independent samples t test, *P < 0.05 versus the control group; n = 5