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. 2017 Nov 26;26(3):718–729. doi: 10.1016/j.ymthe.2017.11.014

Figure 6.

Figure 6

miR-25 TuD Transfer Substantially Reduces Cardiac Fibrosis and Apoptosis-Related Signaling Molecules

(A) Fibrosis markers, Vimentin, and α-SMA showed decreasing trends, but fibrosis inhibition marker SMAD7 showed significant restoration from control to miR-25 TuD-treated mice. In addition, apoptosis signaling molecules Bcl-2, BAX, and caspase-3 were significantly blunted by miR-25 TuD transfer. (B) Masson trichrome staining of HF mice showed significant decrease in fibrosis in miR-25 TuD-transferred mice compared to AAV9 control-transferred mice. (C) TUNEL staining was conducted to visualize apoptosis signaling in sham and HF mice treated with AAV9 control or AAV9 miR-25 TuD. All data are represented as means ± SD (*p < 0.05, **p < 0.01). Red scale bar, 1 mm; black scale bar, 50 μm; white scale bar, 25 μm.