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. 2017 Nov 26;26(3):718–729. doi: 10.1016/j.ymthe.2017.11.014

Figure 7.

Figure 7

The Activity of miR-25 TuD Transfer Is Blunted in SERCA2a KO Mice

(A) Experimental protocol of miR-25 TuD transfer is shown. (B) Echocardiogram data showed that miR-25 TuD had no effect on cardiac function in SERCA2a KO mice. (C) miR-25 TuD decreased endogenous miR-25 levels in WT, and SERCA2 decreased endogenous miR-25 levels in WT and SERCA2a KO mice. (D) SERCA2a expression is unaltered by miR-25 TuD in both groups, although miR-25 expression level is substantially increased in SERCA2a KO mice. All data are represented as means ± SD (*p < 0.05, **p < 0.01).