Figure 2.

Administration of PEG-CBS to I278T Mice Normalizes or Improves Sulfur Metabolites in Tissues

Individual panels show tissue concentrations of non-protein-bound total homocysteine (Hcy; A), non-protein-bound total cysteine (Cys; B), cystathionine (Cth; C), methionine (Met; D), non-protein-bound total glutathione (GSH; E), SAM/SAH ratio (F), homolanthionine (Hlth; G), and lanthionine (Lth; H). Newborn I278T mice (n = 3, hatched bars) were treated from day 2 for up to ∼4 months of age with PEG-CBS (three times a week, s.c., 7.5 mg/kg) and compared to age-matched untreated positive (n = 3, white bars) and negative controls (n = 3, black bars). Columns that are significantly different from each other (p < 0.05) are indicated by having a different letter above the column, with no letter indicating non-significance.