Figure 3.

Administration of PEG-CBS Improves or Normalizes Disturbed Glucose and Lipid Liver Metabolism in I278T Mice

The hydrophilic (A) and lipophilic (B) metabolites were determined by NMR metabolomics in livers from mice treated from day 2 for up to ∼4 months of age with PEG-CBS (three times a week, s.c., 7.5 mg/kg; n = 3, hatched bars) and compared to age-matched untreated positive (n = 3, white bars) and negative controls (n = 3, black bars). (A) Reduced (GSH) and total glutathione, glucose, and glycogen, while (B) compares triacylglycerides (TAG), polyunsaturated fatty acids (PUFA), total unsaturated fatty acids (TUFA), and total fatty acids (TFA). Columns that are significantly different from each other (p < 0.05) are indicated by having a different letter above the column, with no letter indicating non-significance.