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Therapeutic Mechanism of miR-145 Delivery to Overcome SNAI1-Mediated Colorectal Cancer Radiation Resistance
SNAI1 can activate Nanog and repress miR-145. Thus, SNAI1 mediates the CSC program, resulting in a radiation-resistant colorectal cancer cell population. Delivery of miR-145 to target multiple stemness genes, including Nanog, KLF4, and c-Myc, can impair CSC self-renewal capacity and increase sensitivity of radiation therapy.
