Skip to main content
. 2018 Apr 2;115(16):4270–4275. doi: 10.1073/pnas.1716479115

Fig. 5.

Fig. 5.

Voluntary running normalizes transcriptomic alteration of adult NS/PCs in VPA mice. (A) Schematic representation of the isolation of NS/PCs from Ctrl and VPA mice at 12w. RNAs were extracted from these cells and subjected to sequence analysis. (B) Box plots of up- (Left) and down-regulated (Right) DEG expression in NS/PCs of 12w hippocampal DG. Changes of gene expression, in both directions, after VPA exposure were largely normalized by running (RW); *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, n.s indicates not significant. (C) Heat map showing the expression level of up-regulated DEGs in adult VPA mice categorized in the GO term “cell adhesion” (Fig. 2 B and D) in control, VPA, and VPA+RW mice. (D) Heat map indicating the expression level of down-regulated genes in the adult VPA mice categorized in GO term “cell adhesion” and “positive regulation of cell migration” (Fig. 2 C and E) in control, VPA, and VPA+RW mice. (E) Expression level of Cxcr4 in NS/PCs of 12w control, VPA, and VPA+RW mice.