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Nec-1s prevents features of AKI at 96 h. Nec-1s was administered either before or 6 h after induction of folic acid-AKI and then daily until 96 h. (A) Renal function assessed by plasma creatinine levels. (B) Cell death assessed by TUNEL. Data are expressed as mean ± SEM of n = 5 mice per group. *P < 0.05 vs. control; **P < 0.01 vs. control; #P < 0.05 vs. AKI; ##P < 0.01 vs. AKI.
