Table 2.

Parameters of trabecular and cortical bone calculated from micro-CT

Bone parameter	Ct (CMV-Cre) ♀	Fam210a+/− ♀	Ct (Fam210aflox/flox) ♂	TFam210a−/− ♂	Ct (Fam210aflox/flox) ♀	TFam210aMus−/− ♀
Trabecular bone
BV/TV, %	6.251 ± 0.640	5.198 ± 1.152	24.335 ± 0.732	15.975 ± 2.162*	12.924 ± 2.979	7.897 ± 1.222
Tb.Th, mm	0.061 ± 0.001	0.059 ± 0.001	0.057 ± 0.002	0.058 ± 0.001	0.063 ± 0.002	0.059 ± 0.002
Tb.N, 1/mm	1.024 ± 0.099	0.935 ± 0.204	4.280 ± 0.168	2.804 ± 0.304**	2.026 ± 0.416	1.360 ± 0.248
Tb.Sp, mm	0.302 ± 0.018	0.383 ± 0.089	0.257 ± 0.005	0.182 ± 0.006*	0.231 ± 0.019	0.264 ± 0.027
SM1	2.488 ± 0.036	2.476 ± 0.059	1.361 ± 0.072	1.717 ± 0.104*	2.041 ± 0.194	2.376 ± 0.122
Cortical bone
BV/TV, %	42.320 ± 0.486	39.847 ± 0.285*	48.492 ± 0.469	42.093 ± 0.659***	52.281 ± 2.722	47.709 ± 1.606
Co.Th., mm	0.166 ± 0.001	0.150 ± 0.004*	0.211 ± 0.011	0.179 ± 0.005*	0.204 ± 0.006	0.192 ± 0.003
Po.V, %	1.67 × 10−6 ± 3.33 × 10−6	3.33 × 10−5 ± 3.33 × 10−6*	1.02 × 10−5 ± 1.38 × 10−6	3.00 × 10−5 ± 1.29 × 10−6**	1.78 × 10−5 ± 2.87 × 10−6	2.48 × 10−5 ± 7.51 × 10−6

Data represent mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001 according to a two-sided Student’s t test. Ct mice used were all Fam210a^+/+, but, depending on the genotype of the experimental model, a different control was used. Thus, CMV-Cre mice were used as the Ct for the Fam210a^+/−, and all were female aged 56 d; Fam210a^flox/flox littermates (mice expressing allele Tm1c) were used as Ct for TFam210a^−/−, and all were male aged 56 d; Fam210a^flox/flox littermates (mice expressing allele Tm1c) were used as Ct for TFam210aMus^−/−, and all were female aged 56 d. ♀ represents females; ♂ represents males.