Figure 3. Arrhenius behavior of the microscopic rate constants for Aβ42 aggregation.

Arrhenius plots showing the temperature dependence of the rate parameters determined from the analytical fitting in Figs. 1, 2: (a) for k₊, (b) for the combined rate parameter k₊k_n, (c) for the combined rate parameter k₊k₂, in terms of rate constants for elongation (k₊), primary nucleation (k_n) and secondary nucleation (k₂). (d) shows how the data from (a-c), which is plotted as the faded data points and lines, are combined to give the temperature dependencies of the individual rate constants. Interestingly, while k₊ and k_n increase at higher temperatures, k₂ has a weak temperature dependence with the opposite trend. The error bars for the rate parameters represent standard errors from the global fits shown in Figs. 1-2 and for the temperatures indicate the ranges of fluctuations recorded during each experiment.