Table 2.
Values of 24-hour urine relative supersaturation and individual factors by cohort and case status.
| Variable | NHS I Case (N=947) | NHS I Control (N=407) | NHS II Case (N=833) | NHS II Control (N=443) | HPFS Case (N=728) | HPFS Control (N=417) |
|---|---|---|---|---|---|---|
| Calcium Oxalate RS, median (25%, 75%) | 1.54 (1.00, 2.30)a | 1.10 (0.69, 1.60) | 1.64 (1.06, 2.46)a | 1.03 (0.69, 1.60) | 1.97 (1.26, 2.87)a | 1.37 (0.82, 2.16) |
| Calcium phosphate RS, median (25%, 75%) | 0.98 (0.43, 1.86)a | 0.82 (0.40, 1.48) | 1.43 (0.73, 2.59)a | 0.99 (0.52, 1.71) | 1.09 (0.59, 1.95)a | 0.79 (0.42, 1.48) |
| Uric acid RS, median (25%, 75%) | 1.26 (0.50, 2.46)a | 0.85 (0.34, 1.72) | 1.51 (0.60, 2.90)a | 1.04 (0.43, 2.12) | 2.08 (1.08, 3.42) | 1.93 (0.83, 3.46) |
| Creatinine, mg | 1047 (229) | 1030 (217) | 1211 (260) | 1207 (252) | 1673 (370)c | 1606 (373) |
| Calcium, mg | 198 (109)b | 183 (94) | 218 (100)a | 187 (87) | 212 (111)a | 170 (91) |
| Oxalate, mg | 30.0 (11.3)a | 27.7 (10.0) | 28.5 (11.4)a | 25.8 (8.5) | 41.3 (13.2)c | 39.1 (14.7) |
| Uric acid, mg | 444 (162) | 446 (154) | 516 (160) | 506 (158) | 606 (237)b | 638 (214) |
| Citrate, mg | 607 (313)a | 670 (298) | 713 (314)a | 791 (290) | 685 (312) | 714 (301) |
| Potassium, mEq | 58.7 (21.0)a | 62.9 (21.2) | 52.7 (19.8)a | 58.6 (20.3) | 74.9 (24.5)c | 78.8 (26.0) |
| Sodium, meq | 142 (60) | 136 (56) | 153 (63) | 151 (64) | 186 (70)b | 177 (71) |
| Magnesium, mg | 98 (41)c | 106 (39) | 97 (36)b | 103 (39) | 125 (45) | 122 (42) |
| Phosphorus, mg | 757 (246) | 740 (240) | 857 (274) | 826 (278) | 1090 (334)a | 1025 (300) |
| PH | 5.96 (0.53)a | 6.07 (0.48) | 6.01 (0.47)b | 6.07 (0.46) | 5.83 (0.46)b | 5.90 (0.47) |
| Total Volume, L | 1.7 (0.7)a | 2.0 (0.8) | 1.6 (0.7)a | 1.9 (0.8) | 1.6 (0.6)a | 1.8 (0.7) |
HPFS, Health Professionals Follow-up Study; NHS I, Nurses’ Health Study Cohort; NHS II, Nurses’ Health Study II, RS, Relative Supersaturation (calculated using EQUIL2)
Data presented as mean (SD), except where noted
a
p≤0.001 for case compared with control within the cohort
b
p<0.05 for case compared with control within the cohort
c
p≤0.01 for case compared with control within the cohort