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Generation of the type O FMDV 3D mutants with the Asia1 high-fidelity amino acid substitution. (A) Schematic of the FMDV RNA genome and the mutant sites of 3Dpol. (B)The replication ability of FMDV 3D mutants in BHK-21 cells. The mutants and their parent virus (WT) were passaged ten times in BHK-21 cells, and the titers of progeny viruses were determined by a TCID50 assay. The standard deviations (n = 3) of mean virus titers are shown.
