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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Neuroimage. 2018 Feb 27;173:370–383. doi: 10.1016/j.neuroimage.2018.02.047

Figure 4. Cerebellar stimulation drives changes in BOLD signal in various forebrain and midbrain regions.

Figure 4

(A) Changes in BOLD signal are overlaid onto MRI images taken at 0.5 mm intervals. Changes in BOLD signal were induced by a 5 Hz, 100 ms long light train delivered to the cerebellar forelimb region. Significant changes in signal are averaged across the 10 alternating on and off cycles over a 10-minute period. Z-scores were calculated for statistically significant changes in BOLD signal in Arch (n=9) vs control (n=7) animals (p<0.001). Brain regions are labelled according to 3-D mouse brain atlas (Fig. S9). Images are organized from rostral to caudal. Infralimbic Cortex (ILC), Motor Cortex (MC), Anterior Cingulate Cortex (ACC), Septal Nuclei (SpN), Somatosensory Cortex (SSC), Hippocampus (Hpc), Thalamus (Th), Retrosplenial Cortex (RsC), Reticular Formation (RF), Entorhinal Cortex (EC), Periaqueductal Gray (PAG).