Table 1.

Data used for predicting solubility advantage of meloxicam cocrystalized with carboxylic acids

Codea	Cocrystal former	Sa,b	SAa	pKa1	pKa2	ΔGrc,d	pKrc	pMAest	logβ	Cob
M	Meloxicam	0.17	–	4.18	–	2.45	1.73	–	–	0.1e
1	1-Hydroxy-2-naphthoic acid	0.34	0.31	2.70	–	−6.43	−4.53	1.05	−5.58	0.5
2	Salicylic acid	0.26	0.18	2.97	–	−6.96	−4.91	−0.30	−4.61	0.5
3	Succinic acid	0.21	0.09	4.20	5.60	−6.13	−4.32	−5.30	−3.33	0.5
4	4-Hydroxybenzoic acid	0.16	−0.02	4.54	–	−6.34	−4.47	−1.42	−3.04	0.5
5	Glutaric acid	0.13	−0.10	4.30	5.40	−4.59	−3.23	−3.22	−3.25	0.5
6	Maleic acid	0.23	0.13	1.91	6.33	−9.72	−6.85	−8.25	−5.44	0.5
7	l-Malic acid	0.14	−0.08	3.46	5.10	−5.45	−3.84	−3.58	−4.10	0.5
8	Benzoic acid	0.15	−0.04	4.20	–	−6.42	−4.52	−1.14	−3.38	0.5
10	Hydrocinnamic acid	0.16	−0.03	4.57	–	−5.69	−4.01	−1.00	−3.01	0.5
11	Glycolic acid	0.16	−0.02	3.60	–	−7.84	−5.53	−1.55	−3.98	0.5
12	Fumaric Acid	0.18	0.02	3.30	4.44	−7.09	−5.00	−5.72	−4.27	0.5

^aAs reported in [36]

^bIn mg ml⁻¹

^cComputed in this paper

^dExpressed in kcal mol⁻¹

^eSaturated solution in experimental conditions