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. Author manuscript; available in PMC: 2018 Apr 22.
Published in final edited form as: Drug Alcohol Depend. 2017 Aug 1;180:241–259. doi: 10.1016/j.drugalcdep.2017.06.040

Table 2.

Summary of GWAS Results for Alcohol Related Phenotypes

Trait Study Design/Sample N Best SNP SNP p- value Effect Size Effect Allele Gene Ancestry Rep. Reference
ACT Community-based Meta-Analysis 784/739/603 rs7031417 1.40e-08 Z=−5.68 C LOC100129340 EA N Adkins, D.E. (2015)
ACT Community-based Meta-Analysis 784/739/603 rs17053864 1.50e-07 Z=−5.25 G LOC100129340 EA N Adkins, D.E. (2015)
ACT Community-based Meta-Analysis 784/739/603 rs11710497 1.20e-07 Z=−5.29 A SLC6A1 EA N Adkins, D.E. (2015)
ACT Community-based Meta-Analysis 784/739/603 rs7019589 2.30e-07 Z=−5.17 T LOC100129340 EA N Adkins, D.E. (2015)
ACT Community-based Meta-Analysis 784/739/603 rs12257178 4.80e-07 Z=−5.04 A ADRA2A EA N Adkins, D.E. (2015)
AD Case/Control case=1374
control=6468		 rs55768019 7.58e-07 OR=0.80 A HPGD DA N Mbarek, H. (2015)
AD Case/Control case=1374
control=6468		 rs2253612 8.25e-07 OR=0.70 T AOX2P DA N Mbarek, H. (2015)
AD Case/Control case=1374
control=6468		 ra62338789 8.81e-07 OR=0.80 C HPGD DA N Mbarek, H. (2015)
AD Case/Control case=1374
control=6468		 rs56286907 9.20e-07 OR=0.80 C HPGD DA N Mbarek, H. (2015)
AD Case/Control case=1374
control=6468		 rs5009515 9.63e-07 OR=0.80 C HPGD DA N Mbarek, H. (2015)
AD Community-based & Publicly available data Meta-Analysis 2752 rs1229984 6.75e-14 Beta=−0.02 T ADH1B EA Y Gelertner, J. (2014)
AD Community-based & Publicly available data Meta-Analysis 1311 rs2066702 2.18e-09 Beta=−0.02 A ADH1B AA Y Gelertner, J. (2014)
AD Community-based & Publicly available data Meta-Analysis 1311 rs28864441 6.64e-09 Beta=−0.02 T LOC100507053 AA Y Gelertner, J. (2014)
AD Community-based & Publicly available data Meta-Analysis 2752 rs116203444 8.99e-08 Beta=−0.01 C LOC100507053 EA Y Gelertner, J. (2014)
AD Community-based & Publicly available data Meta-Analysis 1311 rs1614972 1.82e-07 Beta=−0.03 T ADH1C AA Y Gelertner, J. (2014)
AD Community-based Meta-Analysis case=1333
control=2168		 rs1789891 1.27e-08 OR=1.46 A Intronic GA Y Frank, J. (2012)
AD Community-based Meta-Analysis case=1333
control=2168		 rs2851300 1.04e-07 OR=1.31 T Intergenic GA N Frank, J. (2012)
AD Community-based Meta-Analysis case=1333
control=2168		 rs169482 1.24e-07 OR=1.31 T Intergenic GA N Frank, J. (2012)
AD Community-based Meta-Analysis case=1333
control=2168		 rs1789924 1.92e-07 OR=1.30 T ADH1C GA N Frank, J. (2012)
AD Community-based Meta-Analysis case=1333
control=2168		 rs4699748 2.51e-07 OR=1.49 A LOC102723576 GA Y Frank, J. (2012)
AD Meta-Analysis of Publicly Available Data (SAGE/COGA) case=1409
control=1518		 rs1057239 2.80e-07 OR=1.32 T KIAA0040 EA Y Zuo, L. (2012)
AD Meta-Analysis of Publicly Available Data (SAGE/COGA) case=1409
control=1518		 rs4949400 2.30e-07 OR=1.32 ? SERINC2 EA N Zuo, L. (2012)
AD Meta-Analysis of Publicly Available Data (SAGE/COGA) case=1409
control=1518		 rs7445832 2.80e-07 OR=1.38 ? HTRIA EA N Zuo, L. (2012)
AD Meta-Analysis of Publicly Available Data (SAGE/COGA) case=1409
control=1518		 rs11583322 4.00e-07 OR=0.76 ? STK40 EA N Zuo, L. (2012)
AD Meta-Analysis of Publicly Available Data (SAGE/COGA) case=1409
control=1518		 rs257906 5.00e-07 OR=1.43 ? SLC27A6 EA N Zuo, L. (2012)
AD Meta-Analysis of Publicly Available Data (COGA/SAGE/OZALC) case=1283
control=1416		 rs6701037 1.86e-07 OR=1.36 C KIAA0040 EA N Wang, K. (2011)
AD Meta-Analysis of Publicly Available Data (COGA/SAGE/OZALC) case=1283
control=1416		 rs6425323 3.13e-07 OR=1.35 T KIAA0040 EA N Wang, K. (2011)
AD Meta-Analysis of Publicly Available Data (COGA/SAGE/OZALC) case=1283
control=1416		 rs1869324 4.71e-07 OR=1.54 A THSD7B EA N Wang, K. (2011)
AD Meta-Analysis of Publicly Available Data (COGA/SAGE/OZALC) case=1283
control=1416		 rs1057302 5.12e-07 OR=1.34 C KIAA0040 EA N Wang, K. (2011)
AD Meta-Analysis of Publicly Available Data(COGA/SAGE/OZALC) case=1283
control=1416		 rs750338 1.47e-06 OR=1.48 C PKNOX2 EA N Wang, K. (2011)
AD Meta-Analysis of Publicly Available Data(COGA/SAGE/OZALC) case=681
control=508		 rs11922615 1.90e-07 NR ? LOC440944 AA N Zuo, L. (2011)
AD Meta-Analysis of Publicly Available Data (COGA/SAGE/OZALC) case=681
control=508		 rs6643238 4.4e-07 NR ? LOC440944 AA N Zuo, L. (2011)
AD Meta-Analysis of Publicly Available Data (COGA/SAGE/OZALC) case=681
control=508		 rs7777391 7.00e-07 NR ? CTTNBP2 AA N Zuo, L. (2011)
AD Meta-Analysis of Publicly Available Data (COGA/SAGE/OZALC) case=681
control=508		 rs3792686 1.70e-06 NR ? D4S234E AA N Zuo, L. (2011)
AD Meta-Analysis of Publicly Available Data (COGA/SAGE/OZALC) case=681
control=508		 rs17028719 4.2e-06 NR ? NPHP4 AA N Zuo, L. (2011)
AD Case/Control case=1897
control=1932		 rs10893366 1.93e-07 OR=1.39 T PKNOX2 AA/EA N Beirut, L.J. (2010)
AD Case/Control case=1897
control=1932		 rs2039617 5.95e-07 OR=0.69 T CC2D2B AA/EA N Beirut, L.J. (2010)
AD Case/Control case=1897
control=1932		 rs9302534 2.73e-06 OR=0.78 C Intergenic AA/EA N Beirut, L.J. (2010)
AD Case/Control case=1897
control=1932		 rs1318937 3.54e-06 OR=1.35 G SH3BP5 AA/EA N Beirut, L.J. (2010)
AD Case/Control case=1897
control=1932		 rs2700648 3.99e-06 OR=1.29 A Intergenic AA/EA N Beirut, L.J. (2010)
AD Case/Control case=847
control=552		 rs4758533 4.80e-05 OR=0.70 ? OSBPL5 EA N Edenberg, H.J. (2010)
AD Case/Control case=1299
control=1560		 rs2247219 6.23e-06 NR ? SEMA3E EA/DA N Lind, P.A. (2010)
AD Case/Control case=1460
control=2332		 rs7590720 9.72e-09 OR=0.74 A Intergenic GA Y Treutlein, J. (2009)
AD Case/Control case=1460
control=2332		 rs1344694 1.68e-08 OR=0.76 G Intergenic GA Y Treutlein, J. (2009)
AD Case/Control case=1460
control=2332		 rs705648 1.78e-08 OR=1.29 C PECR GA Y Treutlein, J. (2009)
AD Case/Control case=1460
control=2332		 rs1864982 3.46e-08 OR=1.36 A PPP2R2B GA Y Treutlein, J. (2009)
AD Case/Control case=1460
control=2332		 rs12388359 3.57e-08 OR=0.62 G CDH13 GA Y Treutlein, J. (2009)
ADF Community-Based Association 812 rs6777876 4.00e-07 NR G Intergenic AA N Kendler, K.S. (2011)
ADF Community-Based Association 812 rs3738843 4.00e-06 NR A Intergenic AA N Kendler, K.S. (2011)
ADF Community-Based Association 812 rs12020569 5.00e-06 NR C AA N Kendler, K.S. (2011)
ADS Community-Based Association 2010 rs12903120 1.09e-06 Beta=−0.18 ? C15orf53 EA Y Wang, J. (2013)
ADS Community-Based Association 2010 rs7168475 2.00e-06 Beta=−0.18 ? C15orf53 EA N Wang, J. (2013)
ADS Community-Based Association 2010 rs12916379 2.79e-06 Beta=−0.17 ? C15orf53 EA N Wang, J. (2013)
ADS Community-Based Association 2010 rs2132157 3.02e-06 Beta=−0.17 ? C15orf53 EA N Wang, J. (2013)
HDF Community-based Meta-Analysis 8766 rs9512637 1.20e-07 Beta=−0.10 C Intergenic EA N Heath, A.C. (2011)
HDF Community-based Meta-Analysis 8766 rs8040009 3.10e-07 Beta=−0.12 T C15orf32 EA N Heath, A.C. (2011)
HDF Community-based Meta-Analysis 8766 rs2369955 1.60e-06 Beta=−0.14 A TMEM108 EA N Heath, A.C. (2011)
HDF Community-based Meta-Analysis 8766 rs10935045 1.70e-06 Beta=−0.13 C TMEM108 EA N Heath, A.C. (2011)
HDF Community-based Meta-Analysis 8766 rs195204 9.10e-06 Beta=0.10 T TNFSF4 EA N Heath, A.C. (2011)
MD Community-Based Association 6325 rs11201929 4.11e-08 Z=5.88 A GRID1 AA/IA/EA/EAA/SAA N Webb, B.T. (2017)
MD Community-Based Association 6325 rs73317758 1.10e-08 Z=−5.71 A COL14A1 AA/IA/EA/EAA/SAA N Webb, B.T. (2017)
MD Community-Based Association 6325 rs11201928 6.46e-08 Z=5.41 A GRID1 AA/IA/EA/EAA/SAA N Webb, B.T. (2017)
MD Community-Based Association 6325 rs4891087 8.60e-08 Z=−5.35 T Intergenic AA/IA/EA/EAA/SAA N Webb, B.T. (2017)
MD Community-Based Association 6325 rs79514906 1.11e-07 Z=−5.31 T Intergenic AA/IA/EA/EAA/SAA N Webb, B.T. (2017)
MD Community-based & Publicly available data Meta-Analysis YalePenn=5543
SAGE=4012		 rs1229984 5.96e-15 Beta=−0.26 A ADH1B EA Y Xu, K. (2015)
MD Community-based & Publicly available data Meta-Analysis YalePenn=5543
SAGE=4012		 rs2066702 2.50e-15 Beta=−0.16 A ADH1B AA Y Xu, K. (2015)
MD Community-based & Publicly available data Meta-Analysis YalePenn=5543
SAGE=4012		 rs1789882 2.10e-09 Beta=−0.13 A ADH1B AA Y Xu, K. (2015)
MD Community-based & Publicly available data Meta-Analysis YalePenn=5543
SAGE=4012		 rs28864441 3.68e-09 Beta=−0.15 T LOC100507053 AA Y Xu, K. (2015)
MD Community-based & Publicly available data Meta-Analysis YalePenn=5543
SAGE=4012		 rs1693457 4.20e-09 Beta=−0.14 C ADH1B AA Y Xu, K. (2015)
MD Community-based & Publicly available data Meta-Analysis YalePenn=5543
SAGE=4012		 rs28600890 5.22e-09 Beta=−0.16 C LOC100507053 AA N Xu, K. (2015)
MD Community-based & Publicly available data Meta-Analysis YalePenn=5543
SAGE=4012		 rs33948359 1.04e-08 Beta=−0.15 CT LOC100507053 AA N Xu, K. (2015)
MD Community-based & Publicly available data Meta-Analysis YalePenn=5543
SAGE=4012		 rs904092 1.45e-08 Beta=−0.13 A LOC100507053 AA N Xu, K. (2015)
MD Community-based & Publicly available data Meta-Analysis YalePenn=5543
SAGE=4012		 rs28470942 4.23e-08 Beta=−0.15 T LOC100507053 AA Y Xu, K. (2015)
MD Community-Based Association 595 rs1858881 1.74e-09 Beta=−0.51 ? ALDH2 HA N Quillen, E.E. (2014)
MD Community-Based Association 595 rs671 4.73e-08 Beta=0.88 ? ALDH2 HA Y Quillen, E.E. (2014)
MD Community-Based Association 595 rs3782886 2.02e-16 Beta=−0.73 ? ALDH2 HA N Quillen, E.E. (2014)
MD Community-Based Association 595 rs4766566 8.70e-12 Beta=−0.55 ? ALDH2 HA N Quillen, E.E. (2014)
MD Community-Based Association 595 rs6490029 7.11e-10 Beta=−0.49 ? ALDH2 HA N Quillen, E.E. (2014)
MD Community-Based Association 595 rs10774610 1.74e-09 Beta=−0.51 ? ALDH2 HA Y Quillen, E.E. (2014)
MD Community-Based Association 595 rs11065750 3.08e-10 Beta=−0.53 ? ALDH2 HA N Quillen, E.E. (2014)
MD Community-Based Association 595 rs925368 5.52e-08 Beta=−0.64 ? ALDH2 HA N Quillen, E.E. (2014)
MD Community-Based Association 595 rs16960688 5.02e-08 Beta=−0.64 ? ALDH2 HA N Quillen, E.E. (2014)
MD Meta-Analysis of Publicly Available Data COGA=2322
SAGE=2593		 rs1229984 2.04e-08 NR T ADH1B EA N Kapoor, M. (2013)
MD Meta-Analysis of Publicly Available Data COGA=2322
SAGE=2593		 rs4758317 7.20e-07 NR C LMO1 EA Y Kapoor, M. (2013)
MD Meta-Analysis of Publicly Available Data COGA=2322
SAGE=2593		 rs59677118 1.16e-06 NR A Intergenic EA N Kapoor, M. (2013)
MD Meta-Analysis of Publicly Available Data COGA=2322
SAGE=2593		 rs55731057 3.31e-06 NR T Intergenic EA N Kapoor, M. (2013)
MD Meta-Analysis of Publicly Available Data COGA=2322
SAGE=2593		 rs67031482 4.07e-06 NR C PLCL1 EA N Kapoor, M. (2013)
MD Meta-Analysis of Publicly Available Data COGA=1059
SAGE=1628
OZALC=3137		 rs11128951 4.27e-08 NR G Intergenic EA N Pan, Y. (2013)
MD Meta-Analysis of Publicly Available Data COGA=1059
SAGE=1628
OZALC=3137		 rs17144687 9.27e-08 NR C Intergenic EA N Pan, Y. (2013)
MD Meta-Analysis of Publicly Available Data COGA=1059
SAGE=1628
OZALC=3137		 rs12108602 1.50e-07 NR G Intergenic EA N Pan, Y. (2013)
MD Meta-Analysis of Publicly Available Data COGA=1059
SAGE=1628
OZALC=3137		 rs2128158 2.28e-07 NR A KCNB2 EA N Pan, Y. (2013)
MD Meta-Analysis of Publicly Available Data COGA=1059
SAGE=1628
OZALC=3137		 rs2929576 2.71e-07 NR T KCNB2 EA N Pan, Y. (2013)

Note: Replication (Rep.) is defined as an additional confirmation of SNP significance at p <.05 within each study. All significant SNPs are included for each study, or the five most significant SNPs if they are non-significanct and p ≤ 5.00e-06. Only one SNP is listed per study if p > 5.00e-06. MD = Maximum Drinks taken in 24 hours ever; AD = Alcohol Dependence; ACT = Alcohol Consumption Trajectory; ADS = Alcohol Dependence Symptom Count; HDF = Heavy Drinking Factor Score; ADF = Alcohol Dependence Factor Score; NR = Not Reported. AA=African Ancestry; EA=European Ancestry; EAA=East Asian Ancestry; SAA=South Asian Ancestry; EA=European Ancestry; DA = Dutch Ancestry; HA = Han Chinese Ancestry; GA = German Ancest