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. Author manuscript; available in PMC: 2018 Apr 22.
Published in final edited form as: Drug Alcohol Depend. 2017 Aug 1;180:241–259. doi: 10.1016/j.drugalcdep.2017.06.040

Table 4.

Summary of GWAS Results for Cannabis Related Phenotypes

Trait Study Design/Sample N Best SNP SNP p-value Effect Size Affect Allele Gene Ancestry Rep. Reference
CDS Meta-Analysis of Publicly Available Data (Yale-Penn/SAGE/ICGHD) 6000 rs143244591 4.32e-10 ? G LOC107986140 - TM4SF18 AA N Sherva, R. (2016)
CDS Meta-Analysis of Publicly Available Data (Yale-Penn/SAGE/ICGHD) 6000 rs146091982 1.33e-09 ? A SLC35G1 AA N Sherva, R. (2016)
CDS Meta-Analysis of Publicly Available Data (Yale-Penn/SAGE/ICGHD) 6000 rs77378271 2.13e-08 ? A CSMD1 AA N Sherva, R. (2016)
CDS Meta-Analysis of Publicly Available Data (Yale-Penn/SAGE/ICGHD) 8754 rs77378271 5.16e-08 ? A CSMD1 EA N Sherva, R. (2016)
CDS Meta-Analysis of Publicly Available Data (Yale-Penn/SAGE/ICGHD) 8754 rs73252553 5.57e-08 ? A LOC105374535 EA N Sherva, R. (2016)
AFU Population-Based Association 6744 rs35487050 1.60e-07 ? ? ZNF181 DA N Minica, C. (2015)
AFU Population-Based Association 6744 rs2434422 3.70e-06 ? ? MIR643 DA N Minica, C. (2015)
AFU Population-Based Association 6744 rs321908 8.50e-06 ? ? MIR643 DA N Minica, C. (2015)
AFU Population-Based Association 6744 rs57523152 3.30e-05 ? ? ZNF766 DA N Minica, C. (2015)
AFU Population-Based Association 6744 rs139570481 2.30e-04 ? ? ZNF766 DA N Minica, C. (2015)
EU Community-Based Meta-Analysis ever=4075
never=6015		 rs1417205 8.41e-07 Beta=−0.06 A GNG5P5 EA N Verweij, K. (2013)
EU Community-Based Meta-Analysis ever=4075
never=6015		 rs10507554 8.41e-07 Beta=0.06 T ELAC2 EA N Verweij, K. (2013)
EU Community-Based Meta-Analysis ever=4075
never=6015		 rs1417202 1.03e-06 Beta=0.06 C NELL1 EA N Verweij, K. (2013)
EU Community-Based Meta-Analysis ever=4075
never=6015		 rs1538803 1.03e-06 Beta=0.06 T LOC105371899 EA N Verweij, K. (2013)
EU Community-Based Meta-Analysis ever=4075
never=6015		 rs9316288 1.31e-06 Beta=−0.06 A LOC101928280 EA N Verweij, K. (2013)
CD Case/Control case=708
control=2346		 rs1019238 6.12e-07 OR=1.45 ? ANKFN1 AA Y Agrawal, A. (2011)
CD Case/Control case=708
control=2346		 rs1431318 9.14e-07 OR=0.71 ? ANKFN1 AA N Agrawal, A. (2011)
CD Case/Control case=708
control=2346		 rs12491921 1.03e-06 OR=1.39 ? LOC101929485 AA Y Agrawal, A. (2011)
CD Case/Control case=708
control=2346		 rs8065311 2.10e-06 OR=1.43 ? ANKFN1 AA Y Agrawal, A. (2011)
CD Case/Control case=708
control=2346		 rs11007350 2.68e-06 OR=0.73 ? RPL21P93 AA N Agrawal, A. (2011)
LU Consortium-Based Meta-Analysis 32330 rs2099149 5.10e-07 Beta=−0.17 T Intergenic EA N Stringer, S. (2016)
LU Consortium-Based Meta-Analysis 32330 rs4471463 9.00e-07 Beta=0.10 T NCAM1 EA N Stringer, S. (2016)
LU Consortium-Based Meta-Analysis 32330 rs4984460 2.20e-06 Beta=−0.11 T LOC107984800 EA N Stringer, S. (2016)
LU Consortium-Based Meta-Analysis 32330 rs58691539 2.20e-06 Beta=−0.29 T Intergenic EA N Stringer, S. (2016)
LU Consortium-Based Meta-Analysis 32330 rs2033867 4.20e-06 Beta=0.23 A Intergenic EA N Stringer, S. (2016)

Note:

a

The effect in the sample represents the direction for this SNP within each sample included in analyses. Replication is defined as an additional confirmation of SNP significance at p <.05 within each study. All significant SNPs are included for each study, or the five most significant SNPs if they are non-significanct and p ≤ 5.00e-06. Only one SNP is listed per study if p > 5.00e-06. LU = Lifetime Cannabis Use scored as yes/no; CDS = Cannabis Dependence Symptom Count; AFU = Age at First Experimental Use; EU = Ever Versus Never used Cannabis. EA = European Ancestry; AA = African Ancestry; DA = Dutch Ancestr