Table 5.
Summary of GWAS Results for Cocaine and Opioid Use Phenotypes
| Trait | Study Design/Sample | N | Best SNP | SNP p-value | Effect Size | Effect Allele | Gene | Ancestry | Rep. | Authors |
|---|---|---|---|---|---|---|---|---|---|---|
| CODS | Community-Based Meta-Analysis | 5697 | rs2629540 | 7.64e-08 | ? | ? | FAM53B | AA/EA | N | Gelernter, J. (2014) |
| COD | Case/Control Meta-Analysis | case=4291 control=1406 |
rs2005290 | 2.86e-07 | ? | ? | OR3A2 | AA/EA | N | Gelernter, J. (2014) |
| CODS | Community-Based Meta-Analysis | 5697 | rs4782559 | 7.54e-07 | ? | ? | CDH13 | AA/EA | N | Gelernter, J. (2014) |
| COD | Case/Control Meta-Analysis | case=4291 control=1406 |
rs6912117 | 2.51e-06 | ? | ? | PXT1 | AA/EA | N | Gelernter, J. (2014) |
| COD | Case/Control Meta-Analysis | case=4291 control=1406 |
rs59955083 | 2.62e-06 | ? | ? | PXT1 | AA/EA | N | Gelernter, J. (2014) |
| ODb | Case/Control Meta-Analysis | case=1167 control=161 |
rs10799590 | 4.30e-09 | OR=0.64 | A | CNH13 | EA | Y | Nelson, E.C. (2016) |
| ODb | Case/Control Meta-Analysis | case=1167 control=161 |
rs12130499 | 4.31e-09 | OR=0.64 | T | CNH13 | EA | Y | Nelson, E.C. (2016) |
| ODb | Case/Control Meta-Analysis | case=1167 control=161 |
rs298733 | 1.25e-08 | OR=0.65 | A | CNH13 | EA | Y | Nelson, E.C. (2016) |
| ODb | Case/Control Meta-Analysis | case=1167 control=161 |
rs1436171 | 2.17e-08 | OR=0.66 | A | CNH13 | EA | Y | Nelson, E.C. (2016) |
| ODb | Case/Control Meta-Analysis | case=1167 control=161 |
rs1369846 | 2.60e-08 | OR=0.66 | C | CNH13 | EA | Y | Nelson, E.C. (2016) |
| OD | Case/Control | case=370 control=134 |
rs4791746 | 2.230e-07 | OR=0.46 | T | Unmapped | HA | N | Kalsi, G. (2016) |
| OD | Case/Control | case=370 control=134 |
rs2288156 | 2.82e-07 | OR=0.39 | T | CCDC42 | HA | N | Kalsi, G. (2016) |
| OD | Case/Control | case=370 control=134 |
17:8631468 | 3.79e-07 | OR=0.47 | C | Unmapped | HA | N | Kalsi, G. (2016) |
| OD | Case/Control | case=370 control=134 |
rs4739179 | 3.62e-06 | OR=0.50 | G | Unmapped | HA | N | Kalsi, G. (2016) |
| OD | Case/Control | case=370 control=134 |
rs1881509 | 4.15e-06 | OR=0.49 | G | BRSK2 | HA | N | Kalsi, G. (2016) |
| ODS | Community-Based and Publicly Available Data Meta-Analysis | 5390 | rs62103177 | 6.68e-10 | ? | ? | KCNG2 | AA | N | Gelernter, J. (2014) |
| ODS | Community-Based and Publicly Available Data Meta-Analysis | 5390 | rs114070671 | 2.26e-09 | ? | ? | APBB2 | AA | Y | Gelernter, J. (2014) |
| ODS | Community-Based and Publicly Available Data Meta-Analysis | 5390 | rs60349741 | 9.26e-09 | ? | ? | KCNC1 | AA | Y | Gelernter, J. (2014) |
| ODS | Community-Based and Publicly Available Data Meta-Analysis | 5390 | rs73411566 | 1.75e-08 | ? | ? | PARVA | AA | Y | Gelernter, J. (2014) |
| ODS | Community-Based and Publicly Available Data Meta-Analysis | 5390 | rs115368721 | 1.92e-08 | ? | ? | APBB2 | AA | Y | Gelernter, J. (2014) |
a
This sample included controls who were opiate users who over time had not progressed to dependent users.
b
Cases are defined as daily injectors, controls are defined as non-dependent misusers.
Note: Replicationm (Rep.) is defined as an additional confirmation of SNP significance at p <.05 within each study. All significant SNPs are included for each study, or the five most significant SNPs if they are non-significanct and p ≤ 5.00e-06. Only one SNP is listed per study if p > 5.00e-06. CODS = Cocaine Dependence Symptom Count; COD = Cocaine Dependence; OD = Opiod Dependence; ODS = Opiod Dependence Symptom Count. EA = European Ancestry; AA = African Ancestry; HA = Han Chinese AncestrY