Table 4.
Longitudinal association between participant characteristics and total IGF-1, IGFBP-3, and IGF-1/IGFBP-3 levels (N=1,387)
| Demographics, health characteristics, and medical conditions (predictor variable) | Log Total IGF-1 | Log IGFBP-3 | Log IGF-1IGFBP-3 | |||
|---|---|---|---|---|---|---|
| B (95% CI) | p | B (95% CI) | p | B (95% CI) | p | |
| Men | 0.44 (0.18, 0.69) | 0.001 | 0.18 (0.004, 0.37) | 0.045 | 0.24 (0.07, 0.42) | 0.007 |
| Time | −0.004 (−0.007, −0.001) | 0.003 | −0.004 (−0.006, −0.003) | <0.001 | 0.0007 (−0.001, 0.002) | 0.448 |
| Men* Time | −0.004 (−0.007, −0.0004) | 0.028 | −0.004 (−0.007, −0.002) | 0.001 | 0.0006 (−0.002, 0.003) | 0.655 |
| BMI | −0.02 (−0.05, 0.002) | 0.070 | −0.009 (−0.03, 0.009) | 0.318 | −0.01 (−0.03, 0.005) | 0.138 |
| Time | −0.01 (−0.02, −0.003) | 0.008 | −0.01 (−0.02, −0.003) | 0.005 | −0.003 (−0.01, 0.004) | 0.366 |
| BMI* Time | 0.0003 (−0.0008, 0.0006) | 0.128 | 0.00008 (−0.0002, 0.0003) | 0.504 | 0.0002 (−0.00006, 0.0005) | 0.140 |
| Cognitive impairment* | 0.34 (−0.25, 0.93) | 0.264 | 0.04 (−0.26, 0.44) | 0.843 | 0.29 (−0.18, 0.77) | 0.221 |
| Time | −0.005 (−0.007, −0.004) | <0.001 | −0.007 (−0.008, −0.006) | <0.001 | 0.002 (0.0006, 0.003) | 0.005 |
| Cognition* Time | −0.004 (−0.01, 0.003) | 0.262 | −0.0007 (−0.005, 0.004) | 0.789 | −0.003 (−0.009, 0.002) | 0.248 |
| CCI | −0.006 (−0.04, 0.03) | 0.773 | −0.03 (−0.06, −0.008) | 0.011 | 0.02 (−0.004, 0.05) | 0.091 |
| Time | −0.007 (−0.01, −0.004) | <0.001 | −0.008 (−0.01, −0.005) | <0.001 | 0.0002 (−0.002, 0.003) | 0.849 |
| CCI* Time | 0.0001 (−0.0003, 0.0006) | 0.568 | 0.0004 (0.00004, 0.0007) | 0.029 | −0.0002 (−0.0005, 0.0002) | 0.340 |
| Hypertension | −0.25 (−0.53, 0.02) | 0.074 | −0.28 (−0.48, −0.08) | 0.005 | 0.009 (−0.20, 0.22) | 0.937 |
| Time | −0.007 (−0.01, −0.004) | <0.001 | −0.008 (−0.01, −0.006) | <0.001 | 0.002 (−0.0008, 0.004) | 0.198 |
| Hypertension* Time | 0.003 (−0.0007, 0.007) | 0.112 | 0.003 (0.0005, 0.006) | 0.021 | 0.0002 (−0.003, 0.003) | 0.910 |
| Diabetes | −0.33 (−0.72, 0.05) | 0.090 | −0.20 (−0.48, 0.07) | 0.148 | −0.14 (−0.44, 0.16) | 0.363 |
| Time | −0.006 (−0.008, −0.004) | <0.001 | −0.007 (−0.008, −0.006) | <0.001 | 0.002 (0.00004, 0.003) | 0.044 |
| Diabetes* Time | 0.004 (−0.001, 0.009) | 0.158 | 0.002 (−0.002, 0.005) | 0.398 | 0.002 (−0.002, 0.006) | 0.265 |
| CABG | −0.28 (−1.08, 0.51) | 0.486 | −0.60 (−1.16, −0.04) | 0.035 | 0.35 (−0.26, 0.96) | 0.266 |
| Time | −0.006 (−0.008, −0.004) | <0.001 | −0.007 (−0.008, −0.006) | <0.001 | 0.002 (0.0002, 0.003) | 0.024 |
| CABG* Time | 0.004 (−0.006, 0.01) | 0.451 | 0.006 (−0.0007, 0.01) | 0.076 | −0.003 (−0.01, 0.005) | 0.468 |
| Myocardial infarction | 0.20 (−0.28, 0.68) | 0.419 | 0.23 (−0.11, 0.57) | 0.183 | −0.04 (−0.40, 0.32) | 0.830 |
| Time | −0.006 (−0.007, −0.004) | <0.001 | −0.006 (−0.008, −0.005) | <0.001 | 0.0009 (−0.0005, 0.002) | 0.209 |
| MI* Time | −0.002 (−0.008, 0.004) | 0.477 | −0.004 (−0.009, 0.00004) | 0.052 | 0.002 (−0.003, 0.007) | 0.367 |
| Stroke | −0.23 (−1.20, 0.73) | 0.632 | −0.32 (−1.00, 0.35) | 0.348 | 0.08 (−0.66, 0.82) | 0.834 |
| Time | −0.006 (−0.008, −0.004) | <0.001 | −0.007 (−0.009, −0.006) | <0.001 | 0.002 (0.0004, 0.003) | 0.011 |
| Stroke* Time | 0.004 (−0.008, 0.02) | 0.522 | 0.004 (−0.004, 0.01) | 0.316 | −0.0003 (−0.009, 0.009) | 0.957 |
| Cancer | 0.19 (−0.20, 0.57) | 0.336 | 0.11 (−0.16, 0.38) | 0.417 | 0.07 (−0.24, 0.37) | 0.670 |
| Time | −0.005 (−0.008, −0.003) | <0.001 | −0.007 (−0.009, −0.005) | <0.001 | 0.002 (0.0003, 0.004) | 0.025 |
| Cancer* Time | −0.002 (−0.007, 0.003) | 0.482 | −0.0009 (−0.004, 0.003) | 0.600 | −0.0007 (−0.005, 0.003) | 0.736 |
| Depression | 0.009 (−0.34, 0.36) | 0.962 | 0.01 (−0.23, 0.26) | 0.913 | 0.005 (−0.27, 0.28) | 0.974 |
| Time | −0.006 (−0.007, −0.004) | <0.001 | −0.007 (−0.008, −0.006) | <0.001 | 0.002 (0.0006, 0.003) | 0.005 |
| Depression* Time | 0.0002 (−0.004, 0.005) | 0.931 | −0.0002 (−0.003, 0.003) | 0.883 | 0.0003 (−0.003, 0.004) | 0.870 |
| Gait speed | 0.46 (−0.04, 0.96) | 0.073 | 0.42 (0.07, 0.76) | 0.018 | 0.03 (−0.37, 0.42) | 0.897 |
| Time | 0.001 (−0.006, 0.009) | 0.723 | −0.0009 (−0.006, 0.004) | 0.734 | 0.002 (−0.004, 0.008) | 0.432 |
| Gait speed* Time | −0.004 (−0.01, 0.002) | 0.180 | −0.005 (−0.009, −0.0002) | 0.039 | 0.0003 (−0.005, 0.005) | 0.898 |
| HRT | −0.08 (−0.60, 0.44) | 0.771 | −0.06 (−0.40, 0.28) | 0.729 | 0.03 (−0.36, 0.41) | 0.888 |
| Time | −0.004 (−0.007, −0.001) | 0.004 | −0.005 (−0.006, −0.003) | <0.001 | 0.0005 (−0.001, 0.003) | 0.601 |
| HRT* Time | −0.001 (−0.008, 0.006) | 0.791 | 0.0001 (−0.005, 0.005) | 0.960 | −0.002 (−0.007, 0.004) | 0.551 |
*
Cognitive impairment defined as z global score<−1.0 SD below age specific norm
BMI, body mass index; CCI, Charlson comorbidity index; CABG, coronary artery bypass grafting; HRT, hormone replacement therapy