Table 2.

Annotated Proteins of C. difficile Strain DH-Associated Accessory Genomic Elements

Protein Annotation of Genes within Each DH-associated AGE	Cramer’s V-Pediatric Cohort (% DH / Non-DH Strains) (n=134)	Cramer’s V-Validation Cohort (% DH / Non-DH Strains) (n=757)
DH-AGE-1 DNA phosphorothioation-dependent restriction protein DptF DNA phosphorothioation-dependent restriction protein DptG DNA phosphorothioation-dependent restriction protein DptH type IV secretion-system coupling DNA-binding domain protein	1 (100/0)	1 (100/0)
DH-AGE-2 multidrug resistance protein pyruvate phosphate dikinase PEP/pyruvate-binding protein TetR family transcriptional regulator	0.92 (100/4)	0.76 (100/4)
DH-AGE-3 acetyltransferase	0.92 (100/4)	0.77 (100/3)
DH-AGE-4 putative sulfurtransferase DndC DNA sulfur modification protein DndD DNA sulfur modification protein DndE	0.89 (100/6)	0.60 (100/9)
DH-AGE-5 bifunctional 5'-methylthioadenosine/S- adenosylhomocysteine nucleosidase/phosphatase	0.86 (100/8)	0.73 (100/5)
DH-AGE-6 putative transcriptional regulator type II restriction enzyme, methylase subunit	0.84 (100/9)	0.57 (100/10)
DH-AGE-7 restriction modification system DNA specificity domain protein	0.84 (100/9)	0.34 (100/29)
DH-AGE-8 conjugative transposon FtsK/SpoIIIE-like protein	0.83 (100/10)	0.16 (98/65)
DH-AGE-9 sporulation integral membrane protein YtvI peptidylarginine deiminase acetyltransferase drug/sodium antiporter cytidylate kinase 2 MerR family transcriptional regulator	0.78 (100/13)	0.45 (100/18)
DH-AGE-10 collagen-binding surface protein	0.78 (100/13)	0.61 (98/8)