Figure 6. Changes in fluxes and concentrations within purine metabolism before and during infection in a human volunteer challenge trial with P. falciparum.

All metabolites or metabolite pools are color-coded to show fold-increases or decreases in concentrations between infection and baseline: red colors represent increased concentrations at post-peak, while green colors represent decreased concentrations at post-peak, according to the log-2 color bar. White boxes indicate no significant changes. Red and green colors of fluxes represent up- or down-regulation at post-peak compared to baseline. Only fluxes with fold-changes greater than 2 are colored; others are shown in blue. The degree of change is indicated by the line thickness. For simplicity, regulatory signals are not shown (cf. Figure 1).