Table 2.
Comparison of clinical characteristics, circulating and urinary markers at baseline between Decliners and Non-decliners with T2D
| Variables | Decliners (n=114) | Non-decliners (n=918) | p-value | AUC |
|---|---|---|---|---|
| A. Clinical characteristics | ||||
| Pre-baseline ACR | 62 (13.4; 654) | 12 (5.9; 32) | <0.001 | 0.71 |
| Gender (Male %) | 67% | 58% | 0.12 | 0.54 |
| Age (ys) | 57 (51; 63) | 57 (50; 61) | 0.051 | 0.56 |
| Duration of DM (ys) | 10 (7; 17) | 10 (6; 15) | 0.27 | 0.52 |
| Insulin Rx (%) | 50% | 56% | 0.33 | 0.53 |
| HbA1c (%) | 8.0 (6.8; 9.2) | 7.6 (6.9; 8.5) | 0.005 | 0.55 |
| BMI (kg/m2) | 32.4 (28.2; 38.3) | 31.1 (26.7; 35.8) | 0.04 | 0.54 |
| SysBP (mmHg) | 140 (129; 155) | 130 (120; 142) | <0.001 | 0.64 |
| DiaBP (mmHg) | 80 (72; 87) | 77 (70; 83) | 0.02 | 0.56 |
| eGFR (ml/min) | 89 (77; 99) | 97 (85; 106) | <0.001 | 0.62 |
| ACE&ARB (%) | 74% | 66% | 0.06 | 0.54 |
| B. Circulating markers at baseline | ||||
| TNFR-1 pg/ml | 1720 (1327; 2210) | 1218 (1030; 1530) | <0.001 | 0.73 |
| KIM-1 pg/ml | 18.8 (9.8; 42.3) | 9.5 (4.9; 15.0) | <0.001 | 0.72 |
| FGF-23 pg/ml | 66 (46; 85) | 55 (43; 70) | 0.002 | 0.58 |
| C. Urinary markers at baseline | ||||
| ACR ug/mg cr | 54 (11.7; 719) | 7.2 (2.9; 25) | <0.001 | 0.75 |
| KIM-1 pg/mg cr | 59 (12; 184) | 16 (3.8; 54) | <0.001 | 0.68 |
| NGAL ng/mg cr | 10.0 (4.2; 21.0) | 7.7 (4.0; 14.5) | 0.04 | 0.54 |
| MCP-1 pg/mg cr | 542 (338; 843) | 306 (162; 501) | <0.001 | 0.70 |
| EGF ng/mg cr | 10.5 (8.1; 15.0) | 13.1 (8.7; 18.6) | 0.003 | 0.58 |
| EGF ng/MCP-1 pg ratio | 19.7 (11.8; 32.4) | 43.3 (25.8; 85.2) | <0.001 | 0.75 |
Quantitative data are presented as median, 1st and 3rd quartiles.
The p values are from Wilcoxon test or Pearson χ2 test.
AUC – area under the ROC curve in univariate logistic regression.