Fig. 3. Typical protocol for oral and sublingual immunotherapy. Initial doses of OIT and SLIT are generally given under medical supervision. Initial dose escalation day(s) starting at subthreshold dose with increasing doses given every 30 minutes over several hours is more common for OIT than for SLIT. Highest tolerated dose given under observation is then continued daily at home, and increased every 1 to 2 weeks under supervision during the build-up phase. The dose achieved at the end of the build-up is continued daily during a maintenance phase. After a few months or years of maintenance, double-blind placebo-controlled food challenge (DBPCFC) to the food is performed to assess for desensitization. Daily dosing may then be discontinued for a period of 4–12 weeks and reintroduced during DBPCFC, to assess sustained tolerance (SU). Reprinted from Journal of Allergy and Clinical Immunology: In Practice (Volume 5), Gernez Y and Nowak-Wegrzyn A, “Immunotherapy for Food Allergy: Are we there yet?”, Page 253, 2017, with permission from Elsevier.