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. 2018 Apr 16;9:345. doi: 10.3389/fphar.2018.00345

FIGURE 5.

FIGURE 5

Ser372 phosphorylation was required for AST to reverse triglyceride accumulation and insulin resistance in HepG2 cells. Mutation of SREBP-1c at Ser372 reversed the effect of AST on glucose consumption (A) and TG (B) and NEFA production (C) in insulin-resistant HepG2 cells. (D) Representative gross morphology of a triglyceride accumulation as visualized by Oil Red O staining. Magnification: ×200∗. AST, astragaloside IV; VEH, vehicle; NEFA, non-esterified fatty acid; IR, insulin resistance; WT, wild type. Data represent the mean ± SD as determined by one-way ANOVA, &p < 0.05, ∗p < 0.05 vs. the WT-IR+VEH group; #p < 0.05 vs. the S372A-IR+VEH group.