Table 1.
The characteristics of the included trials.
| Author | sex ratio (M/F) | age(Y) | Number of patients | Intervention and dose | Duration | Outcomes | ||
|---|---|---|---|---|---|---|---|---|
| Experimental | Control | Experimental | Control | |||||
| Tao et al., 1989 | N/A | N/A | 27 | 31 | TwHF 60 mg/d | PBO | 12 W | SJC, MS, GS, ESR, AE |
| Cibere et al., 2003 | 63/27 | 40.5 | 31 | 30 | TwHF(N/A) | PBO | 6 W | TJC, SJC, MS,GS, ESR,CRP, AE |
| Liu et al., 2006 | 6/24 | 48 | 10 | 10 | TwHF 30 mg, tid | MTX 7.5 mg, qw | 3 M | TJC, SJC, MS, ESR, CRP, AE |
| Yang and Zhang, 2007 | 34/86 | 36.7 | 60 | 60 | TwHF 20 mg, tid | MTX 15 mg, qw | 1 M | TJC, SJC, MS,GS, ESR, CRP, AE |
| Goldbach-Mansky et al., 2009 | 61/60 | 53 | 60 | 61 | TwHF 180 mg/d | SSZ 2 g/d | 24 W | ESR, CRP, AE |
| Yang, 2011 | 13/133 | 54.2 | 74 | 72 | TwHF (contains triptolide 198 μg/d) | MTX 10 mg, qw | 3 M | TJC, SJC, MS,GS, ESR, CRP, AE |
| Lv et al., 2015 | 59/79 | 51.1 | 69 | 69 | TwHF 20 mg,tid | MTX 7.5~12.5 mg, qw | 12 W | TJC, SJC, ESR, CRP, AE |
| 62/76 | 50.8 | 69 | TwHF 20 mg, tid + MTX 7.5~12.5 mg, qw | MTX 7.5~12.5 mg, qw | 12 W | TJC, SJC, ESR, CRP, AE | ||
| Ou et al., 2016 | 23/27 | 45.5 | 25 | 25 | TwHF 10 mg, qd + MTX 10 mg, qw | MTX 10 mg, qw | N/A | MS, ESR, CRP |
| Wang et al., 2017 | 34/62 | 55.5 | 48 | 48 | TwHF 20 mg, tid + MTX 10 mg, qw | MTX 10 mg, qw | 3 M | TJC, SJC, GS, ESR,CRP, AE |
| Cui and Yang, 2016 | 24/62 | 66.9 | 43 | 43 | TwHF 20 mg, tid + LEF 20 mg, qd | LEF 10 mg, qd | 6 M | TJC, SJC, MS, ESR, CRP |
| Li et al., 2017 | 15/45 | 42.3 | 30 | 30 | TwHF 20 mg, tid + MTX 10 mg, qw + LEF 10 mg, qd | MTX 10mg, qw + LEF 10 mg, qd | 12 W | ESR, CRP, AE |
| Wang et al., 2016 | 21/29 | 54.8 | 25 | 25 | TwHF 20 mg, tid + MTX 10 mg, qw | MTX 10 mg, qw | 3 M | TJC, SJC, ESR, CRP, AE |
| Feng and Ma, 2013 | 2/18 | 51.5 | 22 | 20 | MTX 10 mg, qw+ TwHF 60 mg/d | MTX 10 mg, qw | 3 M | TJC, SJC, ESR, CRP, AE |
| Chen et al., 2011 | 20/48 | 39 | 34 | 34 | TwHF 20 mg, tid + MTX 10 mg, qw | LEF 20 mg, qn +MTX 10 mg, qw | 12 W | TJC, SJC, ESR, CRP, AE |
TwHF, Tripterygium wilfordii Hook; TJC, tender joint count; SJC, swollen joint count; MS, morning stiffness; GS, grip strength; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; AE, adverse event; MTX, methotrexate; LEF, leflunomide; PBO, placebo.