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. 2018 Apr 16;9:359. doi: 10.3389/fphar.2018.00359

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Copyright © 2018 Tran, Bergen, Creek, Velkov and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) PCA score plots showing metabolomic variance for untreated samples (blue) and samples treated with polymyxin B (red), mitotane (green) and combination (purple) for each A. baumannii strain along principal components 1 and 2. The degree of separation shows the level of variance between these groups. Principal component 1 axis is responsible for higher level of variance. (B) Venn diagrams showing the number of statistically significant metabolites affected by different treatments (one-way ANOVA, FDR ≤ 0.05; Fisher’s LSD, p ≤ 0.05) in each A. baumannii strain (PMB, polymyxin B; MIT, mitotane).