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. 2018 Apr 16;12:18. doi: 10.3389/fninf.2018.00018

FIGURE 1.

FIGURE 1

Validation domain of a computational model for a range of input parameters and outputs (system responses). Red diamonds represent the validation set points, where comparisons between the computational model and applicable referents were conducted by discrete simulations performed in each referent sub-domain. The range of parameters evaluated establishes the Validation Domain (green ellipse), which will define the extent of the Application Domain (large blue ellipse) where model performance has established credibility. Applications of the model outside of the Application Domain lack validation and have lesser credibility.