Table 3.
Prognostic survival analysis of CYP2C8, CYP2C9, CYP2C18 and CYP2C19 genes in TCGA databases
| Gene | Patients (n = 360) | MST (days) | Crude HR (95% CI) | Crude P value | Adjusted HR (95% CI)a | Adjusted P valuea |
|---|---|---|---|---|---|---|
| CYP2C8 | ||||||
| Low | 180 | 1229 | Ref. | 0.001 | Ref. | 0.004 |
| High | 180 | 2456 | 0.56 (0.39–0.79) | 0.57 (0.39–0.84) | ||
| CYP2C9 | ||||||
| Low | 180 | 1271 | Ref. | 0.001 | Ref. | 0.047 |
| High | 180 | 2456 | 0.56 (0.39–0.80) | 0.67 (0.46–1.00) | ||
| CYP2C18 | ||||||
| Low | 180 | 2456 | Ref. | 0.794 | Ref. | 0.845 |
| High | 180 | 1560 | 0.95(0.67–1.35) | 0.96(0.66–1.40) | ||
| CYP2C19 | ||||||
| Low | 180 | 1229 | Ref. | Ref. | ||
| High | 180 | 2456 | 0.55 (0.38–0.78) | 0.001 | 0.63 (0.43–0.93) | 0.020 |
a
Adjusted P, adjustment for sex, age, TNM stage; CYP2C8, cytochrome P450 family 2 subfamily C member 8; CYP2C9, cytochrome P450 family 2 subfamily C member 9; CYP2C18, cytochrome P450 family 2 subfamily C member 18; CYP2C19, cytochrome P450 family 2 subfamily C member 19. The significance is that all the values are statistically significant.