Table 6.
Outcomes of included studies investigating periprocedural heparin use in patients with ischemic stroke who underwent acute mechanical thrombectomy.
| Reference | sICH, n/N (%) | Mortality, n/N (%) | mRS (0–2), n/N (%) | sICH, OR (95%CI) | Mortality, OR (95%CI) | mRS (0–2), OR (95%CI) | sICH, aOR (95%CI) | Mortality, aOR (95%CI) | mRS (0–2), aOR (95%CI) |
|---|---|---|---|---|---|---|---|---|---|
| Cohort studies and post hoc analyses | |||||||||
| Enomoto et al. (38) | T = 20/409 (5%)c | NR | NR | NR | NR | NR | NR | NR | NR |
| Nahab et al. (33) | T = 2/24 (8%)C = 3/27 (11%)d | T = 8/24 (33%)C = 11/27 (41%) | T = 13/24 (54%)C = 8/27 (30%) | 0.73 (0.11 - 4.77) | 0.73 (0.23 - 2.28) | 2.81 (0.89 - 8.88) | NR | NR | 5.89 (1.34 - 25.92)a |
| Winningham et al. (37) | T = 7/58 (12%), C = 5/115 (4%)d | T = 17/58 (29%)C = 32/115 (28%) | T = 23/58 (40%)C = 30/115 (26%) | 3.02 (0.91 - 9.97) | 1.08 (0.54 - 2.16) | 1.86 (0.95 - 3.64) | NR | NR | 5.30 (1.70 - 16.48)b |
| RCTs investigating effectiveness of endovascular strategies | |||||||||
| Kidwell et al. (27) | T = 3/64 (5%)e | T = 12/64 (19%) | T = 12/64 (19%) | NR | NR | NR | NR | NR | NR |
C, control; CI, confidence interval; aOR, (adjusted) odds ratio; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; NR, not reported; OR, odds ratio; sICH, symptomatic intracranial hemorrhage; T, treated with heparin.
aAdjusted for age and final revascularization success in one study.
bAdjusted for intubation during procedure, postdevice TICI 2b–3, diabetes mellitus, baseline NIHSS score, study device (Trevo vs. Merci), time from symptom onset to arterial puncture (hours), and congestive heart failure in the other.
aSITS-MOST definition (41).
bECASS-II definition (42).
cNo specific definition of sICH given.