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. 2018 Apr 16;9:737. doi: 10.3389/fimmu.2018.00737

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Copyright © 2018 Terrén, Mikelez, Odriozola, Gredilla, González, Orrantia, Vitallé, Zenarruzabeitia and Borrego.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Polyfunctionality of cytokine preactivated natural killer (NK) cells after the preactivation phase. (A) Pie charts representing the percentages of control non-preactivated and cytokine preactivated NK cells expressing CD107a, interferon (IFN)γ, tumor necrosis factor (TNF)α, and/or C-C motif chemokine ligand (CCL)3 (n = 4). (B) Pie charts representing the percentages of control non-preactivated and cytokine-induced memory-like (CIML) NK cells, and CIML NK cells preactivated in the presence of 0.1 and 1 µM ruxolitinib, expressing CD107a, IFNγ, TNFα, and/or CCL3 (n = 4). Differences between pie charts were established with non-parametric permutation test. The p-values are in the boxes below the pie charts. Significant differences are in the red cells.