Table 2.

Functional trajectories and relationships with cognition, stratified by presence of subclinical brain infarct^*

	With PI-SBI (n=247)			Without PI-SBI (n=1044)
Variable	Difference in BI score	95% CI	p-value	Difference in BI score	95% CI	p-value
Annual change in BI	−1.56	−2.05, −1.07	<0.0001	−0.90	−1.06, −0.73	<0.0001
Difference in baseline BI per point of MMSE	−0.20	−0.87, 0.47	0.6	0.16	−0.10, 0.43	0.2
Additional annual change in BI per point of MMSE	−0.09	−0.23, 0.06	0.2	0.07	0.01, 0.12	0.02

^*BI=Barthel index score; SD=standard deviation; PI-SBI=pathology-informed subclinical brain infarct; MMSE=mini-mental state examination score. Model additionally adjusted for: age at time of MRI, sex, race/ethnicity, diabetes, hypertension, physical activity, alcohol use, body mass index, insurance status, depression, and stroke and myocardial infarction occurring during follow-up