FIG. 3.

Histologic images of the proximal tibial metaphysis (von Kossa/tetrachrome stain, 40X) from animals subjected to Sham surgery (T9 laminectomy) or moderate/severe (250 kdyne) spinal cord injury (SCI) alone or in combination with a low- (SCI+LowTE) or high-dose (SCI+HighTE) of testosterone-enanthate (TE). Note reduced mass of black-stained cancellous bone (B) indicative of cancellous osteopenia in SCI animals; high-dose TE (D) fully prevented cancellous bone loss. Values are means±standard error of n=8–9/group. Letters a–d indicate differences from respectively labeled groups at p<0.05 or *p<0.01 (a=vs. SHAM, b=vs. SCI, c=vs. SCI+LowTE, d=vs. SCI+HighTE). Color image is available online at www.liebertpub.com/neu