. 2014 May 1;31(9):834–845. doi: 10.1089/neu.2013.3155

Table 1.

Serum Sex-Steroid Concentrations and Systemic Markers of Bone Formation and Resorption after Sham Surgery (T9 Laminectomy) or Moderate/Severe (250 kdyne) Spinal Cord Injury Alone or in Combination with a Low or High Dose of Testosterone-Enanthate

	SHAM (a)	SCI (b)	SCI+LowTE (c)	SCI+HighTE (d)
Day 7 (nadir) testosterone, ng/mL	3.1±1.9^d	1.8±0.9^{d^*}	2.3±0.5^{d^*}	4.9±0.7^{a,b^,c^}
Day 21 (peak) testosterone, ng/mL	4.5±2.6^{c^,d^}	2.5±1.4^{c^,d^}	9.4±2.6^{a^,b^,d^*}	24.6±3.9^{a^,b^,d^*}
Estradiol, pg/mL	6.1±2.5	5.7±2.3	5.2±1.5	8.2±4.4
Osteocalcin, ng/mL	407±73^{c,d^*}	379±149^d	285±94^a	231±47^{a^*,b}
C-telopeptide, ng/mL	57±17	58±17	53±11	43±14

Values are means±standard deviation of n=8–9/group. Letters a–d indicate differences from respectively labeled groups at p<0.05 or ^*p<0.01 (a=vs. SHAM, b=vs. SCI, c=vs. SCI+LowTE, d=vs. SCI+HighTE). Testosterone/vehicle was administered once weekly via intramuscular injection. Peak and nadir testosterone was evaluated 1 day and 7 days after testosterone/vehicle administration, respectively. All other values were acquired at sacrifice.

SCI, spinal cord injury; SCI+LowTE, spinal cord injury plus low-dose testosterone-enanthate; SCI+HighTE, spinal cord injury plus high-dose testosterone-enanthate.