Table 3.
Cortical Histomorphometric Characteristics at the Tibial Diaphysis after Sham Surgery (T9 Laminectomy) or Moderate/Severe (250 Kdyne) Spinal Cord Injury Alone or in Combination with Low- or High-Dose Testosterone-Enanthate
| SHAM (a) | SCI (b) | SCI+LowTE (c) | SCI+HighTE (d) | |
|---|---|---|---|---|
| Ct.T.Ar, mm2 | 5.7±0.5 | 5.5±0.2 | 5.5±0.4 | 5.2±0.4 |
| Ct.B.Ar, mm2 | 4.7±0.5 | 4.5±0.2 | 4.5±0.4 | 4.3±0.4 |
| Ma.Ar, mm2 | 1.0±0.1 | 1.0±0.1 | 1.0±0.2 | 0.9±0.1 |
| Ct.Wi, μm | 840±61 | 809±64 | 812±54 | 777±65 |
| Ps.MS/BS, % | 47±22b*,c*,d* | 12±8a* | 11±7a* | 10±4a* |
| Ps.MAR, μm/day | 1.4±0.6 | 1.0±0.3 | 1.1±0.4 | 1.1±0.5 |
| Ps.BFR/BS, μm3/μm2/day | 72±62b*,c*,d* | 17±11a* | 15±10a* | 16±13a* |
| Ec.MS/BS, % | 5.5±6.6b,c,d | 0.0±0.0a | 0.0±0.0a | 0.0±0.0a |
| Ec.MAR, μm/day | 0.5±0.5b,c,d | 0.0±0.0a | 0.0±0.0a | 0.0±0.0a |
| Ec.BFR/BS, μm3/μm2/day | 8.9±11.8b,c,d | 0.0±0.0a | 0.0±0.0a | 0.0±0.0a |
Values are means±standard deviation of n=7–9/group. Letters a–d indicate differences from respectively labeled groups at p<0.05 or *p<0.01 (a=vs. SHAM, b=vs. SCI, c=vs. SCI+LowTE, d=vs. SCI+HighTE). SCI, spinal cord injury; SCI+LowTE, spinal cord injury plus low-dose testosterone-enanthate; SCI+HighTE, spinal cord injury plus high-dose testosterone-enanthate. Ct.T.Ar, cortical tissue area; Ct.B.Ar, cortical bone area; Ma.Ar, marrow area; Ct.Wi, cortical width; Ps.MS/BS, periosteal mineralizing surface; Ps.MAR, periosteal mineral apposition rate; Ps.BFR/BS, periosteal bone formation rate; Ec.MS/BS, endocortical mineralizing surface; Ec.MAR, endocortical mineral apposition rate; Ec.BFR/BS, endocortical bone formation rate.