Table 5.
Analysis of Predictors of KS Mortality by Cox Proportional Hazards Models
| Bivariate modela | Multivariate modelb | |||||
|---|---|---|---|---|---|---|
| Variable | Parameter estimate | SE | Hazard ratio | p | Hazard ratio | p |
| Lung involvement (ref = no) | 0.90 | 0.46 | 2.45 | .0494 | 1.05 | .9217 |
| Liver involvement (ref = no) | 1.78 | 0.78 | 5.91 | .0222 | 6.37 | .0737 |
| Karnofsky Score less than or equal to 70 | 1.14 | 0.47 | 3.11 | .0159 | ||
| Karnofsky Score (continuous) | −0.08 | 0.03 | 0.92 | .0029 | 0.94 | .0475 |
| CD4 T cell count under 100 | 1.22 | 0.63 | 3.39 | .0539 | ||
| CD4 T cell count under 50 | 1.21 | 0.56 | 3.34 | .0316 | 2.80 | .1056 |
| log10 viral load >4 log copies/ml | 0.76 | 0.47 | 2.15 | .1010 | 2.15 | .2500 |
| Age at KS diagnosis >50 years | −0.36 | 0.75 | 0.70 | .6317 | 2.25 | .3641 |
a
Bivariate models of survival involve specified variable as predictor and survival duration as outcome.
b
Multivariate model includes lung involvement, liver involvement, Karnofsky score, and CD4 < 50, log viral load >4 log copies/ml, age at KS diagnoses >50 years, as predictors and survival duration as outcome.