Figure 2.

Analysis of IFNAR1 transcripts: (A) structure of IFNAR-1 gene. Alternative splicing and transcription initiation sites produce three distinct transcripts that differ in length. Only transcripts 001 and 003 are translated into proteins, which share only the C-terminal part and a fibronectin type III domain. (B): RNAseq-derived expression levels of the three transcripts from 10 hepatocellular carcinoma (HCC) samples grouped based on their −77VNTR(GT)n genotype. The levels of transcripts 001 (responsible for the production of the receptor) and 002 do not differ significantly between the genotypes. Transcript 003 is expressed only in samples with <8/<8 (GT)n repeats in the −77VNTR polymorphism. The genotypes of HCC RNA samples (A–J) are described in Table 1.