Table 2.
SF-36
| Measure | Visit | N = 48 | Mean (SD) | Median (IQR) | Effect size | P value |
|---|---|---|---|---|---|---|
| PCS | Baseline | 47 | 47.52 (8.77) | 49.04 (10.41) | ||
| Day 75 | 45 | 49.97 (8.05) | 50.69 (9.09) | 0.31 | N.S. | |
| Day 365 | 41 | 52.52 (7.69) | 54.39 (8.05) | 0.54 | <0.0001 | |
| Day 730 | 30 | 52.44 (9.06) | 55.84 (9.60) | 0.39 | 0.0004 | |
| MCS | Baseline | 47 | 49.23 (10.48) | 53.60 (18.34) | ||
| Day 75 | 45 | 53.03 (9.65) | 55.70 (8.04) | 0.28 | 0.0081 | |
| Day 365 | 41 | 51.86 (8.94) | 54.61 (12.44) | 0.28 | N.S. | |
| Day 730 | 30 | 54.40 (7.28) | 56.84 (9.88) | 0.30 | N.S. | |
| Physical Functioning scale | Baseline | 47 | 50.62 (8.04) | 53.71 (9.57) | ||
| Day 75 | 46 | 53.30 (6.58) | 55.63 (5.74) | 0.29 | 0.0034 | |
| Day 365 | 42 | 53.67 (7.17) | 57.54 (3.83) | 0.35 | 0.0005 | |
| Day 730 | 32 | 52.29 (10.26) | 57.54 (3.83) | 0.19 | N.S. | |
| Role Physical scale | Baseline | 47 | 45.69 (10.57) | 48.17 (15.72) | ||
| Day 75 | 45 | 49.17 (9.72) | 52.66 (8.99) | 0.31 | 0.0008 | |
| Day 365 | 42 | 51.70 (7.53) | 54.91 (8.99) | 0.57 | <0.0001 | |
| Day 730 | 30 | 52.67 (9.04) | 57.16 (4.50) | 0.48 | <0.0001 | |
| Bodily Pain scale | Baseline | 47 | 50.52 (10.04) | 51.51 (15.32) | ||
| Day 75 | 46 | 49.96 (10.97) | 53.53 (23.39) | −0.05 | N.S. | |
| Day 365 | 41 | 52.72 (8.24) | 51.51 (15.32) | 0.22 | N.S. | |
| Day 730 | 32 | 53.22 (10.19) | 55.55 (17.34) | 0.08 | N.S. | |
| General Health scale | Baseline | 47 | 44.31 (12.42) | 46.05 (21.39) | ||
| Day 75 | 46 | 50.19 (10.45) | 50.81 (16.64) | 0.49 | <0.0001 | |
| Day 365 | 42 | 51.57 (9.92) | 52.00 (15.69) | 0.57 | <0.0001 | |
| Day 730 | 32 | 51.60 (11.57) | 50.81 (18.55) | 0.39 | 0.0064 | |
| Vitality scale | Baseline | 47 | 48.81 (10.94) | 49.63 (14.85) | ||
| Day 75 | 46 | 54.67 (8.92) | 52.60 (11.88) | 0.51 | 0.0001 | |
| Day 365 | 42 | 53.38 (8.53) | 52.60 (8.91) | 0.40 | 0.0029 | |
| Day 730 | 32 | 55.38 (10.62) | 57.06 (11.88) | 0.44 | 0.0015 | |
| Social Functioning scale | Baseline | 47 | 46.99 (10.78) | 47.31 (20.05) | ||
| Day 75 | 46 | 49.38 (9.72) | 52.33 (10.03) | 0.19 | N.S. | |
| Day 365 | 41 | 50.98 (8.24) | 57.34 (10.03) | 0.30 | N.S. | |
| Day 730 | 32 | 51.70 (10.25) | 57.34 (10.03) | 0.28 | N.S. | |
| Role Emotional scale | Baseline | 47 | 48.02 (10.25) | 49.20 (17.41) | ||
| Day 75 | 44 | 51.58 (8.72) | 56.17 (6.97) | 0.20 | N.S. | |
| Day 365 | 41 | 50.82 (8.43) | 56.17 (6.97) | 0.31 | 0.0090 | |
| Day 730 | 30 | 52.11 (7.49) | 56.17 (6.97) | 0.25 | N.S. | |
| Mental Health scale | Baseline | 47 | 51.54 (9.27) | 53.48 (15.70) | ||
| Day 75 | 46 | 53.83 (9.09) | 56.10 (13.08) | 0.21 | N.S. | |
| Day 365 | 42 | 53.69 (8.20) | 55.12 (7.85) | 0.28 | N.S. | |
| Day 730 | 32 | 54.30 (8.26) | 57.41 (13.08) | 0.22 | N.S. |
The PCS score, MCS score, and eight SF-36 scales stratified by post–initial transplantation study visits. Effect sizes were calculated as the mean individual change from baseline divided by the baseline SD; a value of 0.5 (i.e., half an SD) was determined to be the MID. Higher SF-36 values indicate better functional health status. Tests for change from baseline were performed using the Wilcoxon signed rank test. IQR, interquartile range; N.S., not significant.