Table 3.
EuroQoL
| Measure | Visit | N = 48 | Mean (SD) or NNo Problems (%) | Median (IQR) or NAny Problems (%) | Effect size | P value |
|---|---|---|---|---|---|---|
| VAS | Baseline | 46 | 74.13 (14.66) | 75.00 (15.00) | ||
| Day 75 | 47 | 79.06 (15.97) | 80.00 (20.00) | 0.29 | N.S. | |
| Day 365 | 42 | 82.86 (14.46) | 85.00 (19.00) | 0.71 | <0.0001 | |
| Day 730 | 31 | 85.74 (15.36) | 91.00 (18.00) | 0.73 | <0.0001 | |
| Health Preference Weight | Baseline | 47 | 0.87 (0.12) | 0.83 (0.22) | ||
| Day 75 | 47 | 0.86 (0.15) | 0.84 (0.17) | −0.06 | N.S. | |
| Day 365 | 41 | 0.86 (0.15) | 0.84 (0.17) | −0.04 | N.S. | |
| Day 730 | 32 | 0.88 (0.18) | 1.00 (0.18) | 0.09 | N.S. | |
| Usual Activities | Baseline | 47 | 32 (68.09%) | 15 (31.91%) | ||
| Day 75 | 47 | 35 (74.47%) | 12 (25.53%) | N.S. | ||
| Day 365 | 42 | 33 (78.57%) | 9 (21.43%) | N.S. | ||
| Day 730 | 32 | 27 (84.38%) | 5 (15.63%) | 0.0143 | ||
| Anxiety/Depression | Baseline | 47 | 32 (68.09%) | 15 (31.91%) | ||
| Day 75 | 47 | 34 (72.34%) | 13 (27.66%) | N.S. | ||
| Day 365 | 42 | 29 (69.05%) | 13 (30.95%) | N.S. | ||
| Day 730 | 32 | 23 (71.88%) | 9 (28.13%) | N.S. | ||
| Mobility | Baseline | 47 | 38 (80.85%) | 9 (19.15%) | ||
| Day 75 | 47 | 40 (85.11%) | 7 (14.89%) | N.S. | ||
| Day 365 | 41 | 34 (82.93%) | 7 (17.07%) | N.S. | ||
| Day 730 | 32 | 26 (81.25%) | 6 (18.75%) | N.S. | ||
| Pain/Discomfort | Baseline | 47 | 25 (53.19%) | 22 (46.81%) | ||
| Day 75 | 47 | 27 (57.45%) | 20 (42.55%) | N.S. | ||
| Day 365 | 42 | 24 (57.14%) | 18 (42.86%) | N.S. | ||
| Day 730 | 32 | 22 (68.75%) | 10 (31.25%) | N.S. | ||
| Self-Care | Baseline | 47 | 45 (95.74%) | 2 (4.26%) | ||
| Day 75 | 47 | 46 (97.87%) | 1 (2.13%) | N.S. | ||
| Day 365 | 42 | 39 (92.86%) | 3 (7.14%) | N.S. | ||
| Day 730 | 32 | 29 (90.63%) | 3 (9.38%) | N.S. |
The EQ-5D VAS, Health Preference Weight, and five dimensions stratified by post–initial transplantation study visits. Effect sizes were calculated as the mean individual change from baseline divided by the baseline SD; a value of 0.5 (i.e., half an SD) was determined to be the MID. No effect size calculations were made for the five categorical dimensions. The five EQ-5D dimensions comprise three-level ordinal categorical responses. These responses were dichotomized as either “No Problems” or “Any Problems” based on a scoring option referenced in the EQ-5D user guide (29). Larger EQ-5D VAS and Health Preference Weight values indicate better health utility. Tests for change from baseline were performed using the Wilcoxon signed rank test for continuous outcomes and the McNemar test for categorical outcomes. IQR, interquartile range; N.S., not significant.