Table 1.
Incidence of disability and remission from physical disability according to intervention group: the Look AHEAD study
| Intervention condition |
||||
|---|---|---|---|---|
| DSE | ILI | IRR (95% CI) | P value | |
| Overall population (n = 5,137) | 2,570 | 2,567 | — | |
| Moderate/severe disability cases | 980 | 930 | — | |
| Moderate/severe per 100 person-years | 6.8 (5.8–7.9) | 6.0 (5.6–6.4) | 0.88 (0.81–0.96) | < 0.01 |
| Severe per 100 person-years | 2.5 (1.9–3.2) | 2.2 (2.0–2.4) | 0.87 (0.75–1.01) | 0.07 |
| Disability remission per 100 disabled persons/year* | 30.1 (23.6–38.5) | 34.8 (31.4–38.5) | 1.06 (0.92–1.23) | 0.42 |
| Deaths (n, %) | 199 (7.7) | 171 (6.7) | — | |
| Yearly mortality rate per 100 person-years | 0.96 (0.67–1.36) | 0.81 (0.69–0.94) | 0.86 (0.70–1.06) | 0.15 |
| Men (n = 2,079) | 1,037 | 1,042 | ||
| Moderate/severe disability cases | 345 | 346 | — | |
| Moderate/severe per 100 person-years | 5.2 (4.0–6.6) | 5.1 (4.6–5.7) | 0.99 (0.85–1.15) | 0.91 |
| Severe per 100 person-years | 2.1 (1.4–3.2) | 1.9 (1.6–2.3) | 0.96 (0.75–1.21) | 0.70 |
| Disability remission per 100 disabled persons/year | 24.1 (16.0–36.3) | 32.5 (27.5–38.4) | 1.23 (0.96–1.56) | 0.10 |
| Deaths (n, %) | 117 (11.3) | 93 (8.9) | — | |
| Yearly mortality rate per 100 person-years | 1.4 (0.9–2.3) | 1.1 (0.9–1.4) | 0.79 (0.60–1.03) | 0.08 |
| Women (n = 3,058) | 1,533 | 1,525 | ||
| Moderate/severe disability cases | 635 | 584 | — | |
| Moderate/severe per 100 person-years | 8.2 (6.7–9.9) | 6.7 (6.2–7.3) | 0.81 (0.73–0.91) | < 0.01 |
| Severe per 100 person-years | 2.8 (2.0–3.9) | 2.3 (2.0–2.7) | 0.81 (0.67–0.99) | 0.04 |
| Disability remission per 100 disabled persons/year | 34.4 (25.3–46.6) | 36.3 (31.9–41.2) | 0.98 (0.82–1.17) | 0.81 |
| Deaths (n, %) | 82 (5.4) | 78 (5.1) | — | |
| Yearly mortality rate per 100 person-years | 0.6 (0.4–1.0) | 0.6 (0.5–0.8) | 0.96 (0.70–1.30) | 0.77 |
| No CVD (n = 4,424) | 2,223 | 2,201 | ||
| Moderate/severe disability cases | 842 | 786 | — | |
| Moderate/severe per 100 person-years | 8.2 (6.9–9.6) | 7.1 (6.6–7.6) | 0.87 (0.79–0.95) | < 0.01 |
| Severe per 100 person-years | 2.4 (1.8–3.2) | 2.0 (1.8–2.3) | 0.83 (0.71–0.98) | 0.02 |
| Disability remission per 100 disabled persons/year | 34.2 (26.4–44.3) | 37.9 (34.1–42.2) | 1.05 (0.90–1.22) | 0.56 |
| Deaths (n, %) | 138 (6.2) | 116 (5.3) | — | |
| Yearly mortality rate per 100 person-years | 0.8 (0.5–1.2) | 0.6 (0.5–0.8) | 0.84 (0.66–1.08) | 0.17 |
| CVD (n = 713) | 347 | 366 | ||
| Moderate/severe disability cases | 138 | 144 | — | |
| Moderate/severe per 100 person-years | 9.9 (6.7–14.7) | 9.8 (8.4–11.5) | 0.98 (0.78–1.24) | 0.87 |
| Severe per 100 person-years | 2.9 (1.6–5.5) | 3.2 (2.5–4.1) | 1.14 (0.78–1.65) | 0.50 |
| Disability remission per 100 disabled persons/year | 15.3 (7.3–31.7) | 21.0 (15.5–28.4) | 1.17 (0.75–1.82) | 0.49 |
| Deaths (n, %) | 61 (17.6) | 55 (15.0) | — | |
| Yearly mortality rate per 100 person-years | 2.4 (1.3–4.6) | 2.0 (1.6–2.6) | 0.86 (0.60–1.25) | 0.43 |
Data are n or n (95% CIs) unless otherwise indicated.
*Analyses of disability incidence excluded persons with disability at baseline.