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Competition of binding reactivities of nine mAbs to ManLAM by monomeric glycans and soluble ManLAM. (A) Competition curves for binding of A194-01 to ManLAM by soluble glycans, PILAM, and ManLAM. (B) Structures of competing glycans used in this assay. (C) Tabulation of glycan and ManLAM concentrations (micromolar) required for 50% inhibition of binding of the mAbs tested to ManLAM.
