Table 5.

Meta-regression analyses

	Anatomical label	Peak MNI coordinate (x, y, z)	Number of voxels	SDM-Z value	p value
Effect of age	Association of regional glucose metabolism effect size and older mean age of aMCI converters
	Left middle temporal gyrus (BAs 21 and 20)	−54, 4, − 28	152	−1.64	0.00024
	Left middle temporal gyrus (BA 37)	−56, −58, −2	64	−1.69	0.00016
	Left superior /middle frontal gyri, orbital part (BA 11)	−18, 58, − 14	53	1.73	0.000076
Effect of illness severity	Association of regional glucose metabolism effect size and lower mean MMSE scores of aMCI converters
	Left middle frontal gyrus (BA 9)	−24, 22, 42	21	−2.74	0.00014
	Left temporal pole (BAs 28 and 36)	−20, 8, −34	13	−2.69	0.00017
Effect of follow-up duration	Association of regional glucose metabolism effect size and longer mean follow-up duration
	Left middle frontal gyrus (BAs 46 and 9)	−30, 40, 30	255	−3.30	0.000037

Abbreviations: SDM Seed-based d Mapping, MNI Montreal Neurological Institute, aMCI amnestic mild cognitive impairment, PCC posterior cingulate cortex, ACC anterior cingulate cortex, BA Brodmann area